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| | 7-Methoxy-4(1H)-quinazolinone Basic information |
| Product Name: | 7-Methoxy-4(1H)-quinazolinone | | Synonyms: | 4(3H)-Quinazolinone, 7-methoxy-;7-Methoxyquinazolin-4(1H)-one;7-Methoxy-4(3h)-quinazolinone;7-methoxy-1,4-dihydroquinazolin-4-one;7-Methoxy-3H-quinazolin-4-one;7-Methoxy-4-quinazolinol;7-methoxyquinolineazoleline-4(1H)-one;7-Methoxyquinazolin-4(3H)-one | | CAS: | 16064-24-7 | | MF: | C9H8N2O2 | | MW: | 176.17 | | EINECS: | | | Product Categories: | | | Mol File: | 16064-24-7.mol |  |
| | 7-Methoxy-4(1H)-quinazolinone Chemical Properties |
| Melting point | 257-258℃ | | Boiling point | 338.7±44.0 °C(Predicted) | | density | 1.32 | | storage temp. | 2-8°C | | pka | 1.51±0.20(Predicted) | | Appearance | Brown to black Solid |
| | 7-Methoxy-4(1H)-quinazolinone Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 7-methoxyquinazolin-4(1H)-one from formamidine acetate and 2-amino-4-methoxybenzoic acid was as follows:
1. 2-Amino-4-methoxybenzoic acid (4.85 g, 28.9 mmol) and formamidine acetate (18.49 g, 177.8 mmol) were mixed in 100 mL of 2-methoxyethanol.
2. The reaction mixture was heated to reflux and stirred under these conditions for 12 hours.
3. After completion of the reaction, the mixture was cooled to 25 °C. The reaction was carried out with 0.01 M
4. Dilute the cooled reaction mixture with 0.01 M aqueous ammonia solution (100 mL).
5. Continue stirring at 25 °C for 30 min.
6. Collect the light brown solid product formed by filtration.
7. Wash the solid product with 0.01 M aqueous ammonia solution. 8.
8. The final product 7-methoxyquinazolin-4(1H)-one was obtained by high vacuum drying in a yield of 11.5 g (73% yield).
Product characterization data:
NMR (δ, ppm): 12.10 (s, br, 1H), 8.05 (m, 2H), 7.10 (m, 2H), 3.90 (s, 3H); m/z 167. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 17, p. 4963 - 4966
[2] Patent: WO2007/71963, 2007, A2. Location in patent: Page/Page column 52
[3] Patent: CN104447769, 2016, B. Location in patent: Paragraph 0056-0057 |
| | 7-Methoxy-4(1H)-quinazolinone Preparation Products And Raw materials |
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