m-PEG3-Sulfone-PEG2-OH

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m-PEG3-Sulfone-PEG2-OH manufacturers
m-PEG3-Sulfone-PEG2-OH Basic information
Product Name:m-PEG3-Sulfone-PEG2-OH
Synonyms:m-PEG3-Sulfone-PEG2-OH;m-PEG3-Sulfone-PEG3;3,6,12,15,18-Pentaoxa-9-thianonadecan-1-ol, 9,9-dioxide
CAS:1919045-00-3
MF:C13H28O8S
MW:344.42
EINECS:
Product Categories:
Mol File:1919045-00-3.mol
m-PEG3-Sulfone-PEG2-OH Structure
m-PEG3-Sulfone-PEG2-OH Chemical Properties
Boiling point 498.2±45.0 °C(Predicted)
density 1.173±0.06 g/cm3(Predicted)
pka14.36±0.10(Predicted)
Safety Information
MSDS Information
m-PEG3-Sulfone-PEG2-OH Usage And Synthesis
Descriptionm-PEG3-Sulfone-PEG2-OH is a PEG linker containing sulfone and hydroxyl moieties. The sulfone can react with thiol groups of proteins. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Usesm-PEG3-Sulfone-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
m-PEG3-Sulfone-PEG2-OH Preparation Products And Raw materials
Tag:m-PEG3-Sulfone-PEG2-OH(1919045-00-3) Related Product Information
m-PEG3-Mal m-PEG3-Sulfone-PEG3-azide Diethylene Glycol 2-Bromoethyl Methyl Ether m-PEG3-Sulfone-PEG3-acid m-PEG3-NHS ester m-PEG3-Sulfone-PEG4-propargyl m-PEG3-aldehyde 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol 2-[2-(2-METHOXYETHOXY)ETHOXY]ACETIC ACID m-PEG3-Sulfone-PEG3-t-butyl ester m-PEG3-Tos