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Nextpeptide Inc |
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| | m-PEG3-Sulfone-PEG4-propargyl Basic information |
| | m-PEG3-Sulfone-PEG4-propargyl Chemical Properties |
| Boiling point | 536.0±50.0 °C(Predicted) | | density | 1.137±0.06 g/cm3(Predicted) |
| | m-PEG3-Sulfone-PEG4-propargyl Usage And Synthesis |
| Description | m-PEG3-Sulfone-PEG4-propargyl is a sulfonated PEG linker containing a propargyl group. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | m-PEG3-Sulfone-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG3-Sulfone-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | m-PEG3-Sulfone-PEG4-propargyl Preparation Products And Raw materials |
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