- Afegostat
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- $2820.00
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2026-05-19
- CAS:169105-89-9
- Purity:
- Supply Ability: 10g
- Afegostat
-
-
2025-10-28
- CAS:169105-89-9
- Purity:
- Supply Ability: 10g
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| | Isofagomine, hydrochloride Basic information |
| Product Name: | Isofagomine, hydrochloride | | Synonyms: | (3R,4R,5R)-5-(HYDROXYMETHYL)-3,4-PIPERIDINEDIOL, HYDROCHLORIDE;SOFAGOMINE, HYDROCHLORIDE;5-(HYDROXYMETHYL)PIPERIDINE-3,4-DIOL;(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol,HCl;IsofagomineHydrochlroide;(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol;3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)-;5-Hydroxymethyl-3,4-piperidinediol | | CAS: | 169105-89-9 | | MF: | C6H13NO3 | | MW: | 147.17 | | EINECS: | | | Product Categories: | pharmacetical;Inhibitors | | Mol File: | 169105-89-9.mol |  |
| | Isofagomine, hydrochloride Chemical Properties |
| Boiling point | 317.2±37.0 °C(Predicted) | | density | 1.279±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | Soluble in DMSO | | pka | 14.19±0.60(Predicted) | | form | Oil | | color | Colorless to light yellow |
| | Isofagomine, hydrochloride Usage And Synthesis |
| Chemical Properties | Yellow Low-Melting Solid | | Uses | Isofagomine is a selective Inhibitor of β-Glycosidases. | | Uses | A selective and very strong inhibitor of Glucosidase (Ki0.11uM) | | Definition | ChEBI: Afegostat is a member of piperidines. | | in vivo | Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1]. |
| | Isofagomine, hydrochloride Preparation Products And Raw materials |
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