- WAY316606
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-
2026-06-08
- CAS:915759-45-4
- Min. Order: 10g
- Purity: 99%
- Supply Ability: 10 kg
- WAY 316606
-
- $43.00
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2026-06-02
- CAS:915759-45-4
- Purity: 99.76%
- Supply Ability: 10g
- WAY 316606
-
-
2025-12-26
- CAS:915759-45-4
- Min. Order: 1KG
- Purity: 98
- Supply Ability: 10000KGS
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| | BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Basic information |
| Product Name: | BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- | | Synonyms: | BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-;5-(Phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide;WAY-316606;WAY 316606;WAY316606;5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide;CS-2786;way-316606 /way 316606;2-[(2S)-2-Oxiranylmethyl]-1H-isoindole-1;WAY 316606 HCl(free base) | | CAS: | 915759-45-4 | | MF: | C18H19F3N2O4S2 | | MW: | 448.48 | | EINECS: | 1592732-453-0 | | Product Categories: | | | Mol File: | 915759-45-4.mol |  |
| | BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Chemical Properties |
| Boiling point | 601.1±65.0 °C(Predicted) | | density | 1.50±0.1 g/cm3(Predicted) | | solubility | DMF: 3 mg/ml; DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml | | pka | 8.76±0.20(Predicted) | | form | Powder | | color | White to off-white | | InChI | InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2 | | InChIKey | ITBGJNVZJBVPLJ-UHFFFAOYSA-N | | SMILES | C1(S(NC2CCNCC2)(=O)=O)=CC(S(C2=CC=CC=C2)(=O)=O)=CC=C1C(F)(F)F |
| | BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Usage And Synthesis |
| Description | WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP-1; IC50 = 0.5 μM). It increases Wnt signaling in U2OS osteosarcoma cells (EC50 = 0.65 μM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM. | | Uses | WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 μM[1]. | | Definition | ChEBI: WAY-316606 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonic acid with the primary amino group of piperidin-4-amine. An inhibitor of secreted Frizzled-Related Protein-1 (sFRP-1). It has a role as a secreted frizzled-related protein 1 inhibitor. It is a sulfone, a sulfonamide, a member of (trifluoromethyl)benzenes, a member of piperidines and a secondary amino compound. | | in vivo | WAY-316606 increases bone formation when tested in a neonatal murine calvarial assay. WAY-316606 increases total bone area up to 60% in a dose-dependent manner with an EC50 of about 1 nM. WAY-316606 exhibits moderate to low inhibition of cytochrome p450 isozymes (3A4, 2D6, 2C9) and good stability in rat and human liver microsomes (t1/2>60 min in each species). In female Sprague-Dawley rats, WAY-316606 exhibits high plasma clearance (77 mL/min/kg, greater than hepatic blood flow) following a single intravenous bolus dose (2 mg/kg), which results in a rapid decline of drug exposure in the plasma despite the route of administration[2]. | | References | [1] Moore, WJ, et al. Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides. Journal of Medicinal Chemistry (2009), 52(1), 105-116. DOI:10.1021/jm801144h
[2] Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone. 2009 Jun;44(6):1063-8. DOI:10.1016/j.bone.2009.02.013 |
| | BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Preparation Products And Raw materials |
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