| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
177-54423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:WAY-204688
CAS:796854-35-8
Purity:98% HPLC LCMS Package:100mg;500mg;1g
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| | WAY-204688 Basic information |
| Product Name: | WAY-204688 | | Synonyms: | WAY-204688;1-Piperidinepropanenitrile, α-[(S)-(2-methoxyphenyl)-1-naphthalenylmethyl]-α-methyl-β-oxo-4-[3-(trifluoromethyl)phenyl]-, (αS)-;SIM-688;(2S,3S)-3-(2-Methoxyphenyl)-2-methyl-3-(naphthalen-1-yl)-2-(4-(3-(trifluoromethyl)phenyl)piperidine-1-carbonyl)propanenitrile | | CAS: | 796854-35-8 | | MF: | C34H31F3N2O2 | | MW: | 556.63 | | EINECS: | | | Product Categories: | | | Mol File: | 796854-35-8.mol |  |
| | WAY-204688 Chemical Properties |
| Boiling point | 708.7±60.0 °C(Predicted) | | density | 1.231±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | -1.66±0.40(Predicted) | | color | White to off-white |
| | WAY-204688 Usage And Synthesis |
| Uses | WAY-204688 is an estrogen receptor (ER-α) selective, orally active inhibitor of NF-κB transcriptional activity with an IC50 of 122±30 nM for NF-κB-luciferase (NF-κB-luc) in HAECT-1 cells. | | in vivo | WAY-204688 (5 mg/kg per day, po daily for 5 weeks) is evaluated in vivo for the ability to inhibit four proinflammatory genes (MHC, invariant chain (MHI), VCAM-1, RANTES, and TNF-α). The effect of WAY-204688 on induction of the gene products and on uterine wet weight is compared to that of 17α-ethinyl 17β-estradiol (EE at 10 μg/kg per day) in the same paradigm. Further characterization of WAY-204688 is carried out in several preclinical models of inflammatory disease. In the Lewis rat adjuvant-induced arthritis model (AIA), WAY-204688 is active at a dose of 0.3 mg/kg per day, po[1]. | | IC 50 | NF-κB-luc: 122 nM (IC50, in HAECT-1 cell); NF-κB | | References | [1] Caggiano TJ, et al. Estrogen receptor dependent inhibitors of NF-kappaB transcriptional activation-1 synthesis and biological evaluation of substituted 2-cyanopropanoic acid derivatives: pathway selective inhibitors of NF-kappaB, a potential treatment for rheumatoid arthritis. J Med Chem. 2007 Nov 1;50(22):5245-8. DOI:10.1021/jm701013k |
| | WAY-204688 Preparation Products And Raw materials |
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