2-Bromo-4-thiazolecarboxylic acid

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2-Bromo-4-thiazolecarboxylic acid Basic information
Uses
Product Name:2-Bromo-4-thiazolecarboxylic acid
Synonyms:2-BROMO-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-BROMO-4-THIAZOLECARBOXYLIC ACID;2-Bromo-1,3-thiazole-4-carboxylic acid 97%;JR-14086, 2-Bromothiazole-4-carboxylic acid, 97%;4-Thiazolecarboxylic acid, 2-bromo-;2-Bromo-4-carboxy-1,3-thiazole;2-Bromothiazole-4-carboxylic Acid >;2-BROMO-1,3-THIAZOLE-4-CARBOXYLATE
CAS:5198-88-9
MF:C4H2BrNO2S
MW:208.03
EINECS:
Product Categories:ADVANCED CHEMICALS;Heterocycles;Carboxylic Acids;Thiazoles, Isothiazoles & Benzothiazoles;Organohalides;Thiazole;Carboxylic Acids;Thiazoles, Isothiazoles &Benzothiazoles;Organic acids;API intermediates;Miscellaneous;blocks;Bromides;Carboxes;Thiazoles
Mol File:5198-88-9.mol
2-Bromo-4-thiazolecarboxylic acid Structure
2-Bromo-4-thiazolecarboxylic acid Chemical Properties
Melting point 212-214
Boiling point 350.0±15.0 °C(Predicted)
density 2.062±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka3.13±0.10(Predicted)
form powder to crystal
color White to Almost white
λmax243nm(MeOH)(lit.)
InChIInChI=1S/C4H2BrNO2S/c5-4-6-2(1-9-4)3(7)8/h1H,(H,7,8)
InChIKeyBEGREHRAUWCAHV-UHFFFAOYSA-N
SMILESS1C=C(C(O)=O)N=C1Br
CAS DataBase Reference5198-88-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
WGK Germany 3
Hazard Note Irritant
HS Code 29341000
Storage Class11 - Combustible Solids
MSDS Information
2-Bromo-4-thiazolecarboxylic acid Usage And Synthesis
UsesThiazole compounds are important pharmaceutical and chemical intermediates, characterized by low toxicity, excellent biological activities (such as acaricidal, bactericidal, and inhibitory effects on insect pheromone synthesis), and diverse structural variations. Thiazole 2-bromo-4-thiazolium carboxylic acid is a key intermediate in the synthesis of thiabendazole.
Chemical PropertiesPale yellow crystals
Synthesis

Ethyl 2-aminothiazole-4-carboxylate was synthesized solvent-free from thiourea and ethyl bromopyruvate as reagent, then ethyl 2-bromothiazole-4-carboxylate was obtained by high-temperature diazotization with DM SO and sodium nitrite, and finally the target 2-bromo-4-thiazolecarboxylate was obtained by saponification with potassium carbonate-methanol solution

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2-Bromo-4-thiazolecarboxylic acid Preparation Products And Raw materials
Raw materialsMethyl 2-bromothiazole-4-carboxylate-->Ethyl 2-bromothiazole-4-carboxylate
Preparation Products2-Iodo-4-thiazolecarboxylic acid
Tag:2-Bromo-4-thiazolecarboxylic acid(5198-88-9) Related Product Information
2-Bromothiazole 2,2'-Dithiobis(benzothiazole) Benzothiazole Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Fosthiazate 2-Methyl-4-isothiazolin-3-one Ethyl 2-bromothiazole-4-carboxylate Ethyl 2-bromothiazole-5-carboxylate 5-Thiazolecarboxylic acid, 2,4-dibromo- Methyl 2-bromothiazole-5-carboxylate METHYL 2-BROMOTHIAZOLE-4-CARBOXYLATE ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 2-BROMO-5-THIAZOLECARBOXYLIC ACID 4-Bromo-5-thiazolecarboxylic acid ethyl ester 2,5-Dibromo-thiazole-4-carboxylic acid ethyl ester 2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid Bromine 2,5-DIBROMO-THIAZOLE-4-CARBOXYLIC ACID