4'-甲氧基查耳酮
| 中文名称 | 4'-甲氧基查耳酮 |
|---|---|
| 中文同义词 | 4'-甲氧基查耳酮,97%;1-(4-甲氧基苯基)-3-苯基丙-2-烯-1-酮;4'-甲氧基查尔酮;4'-甲氧基查耳酮;4'-甲氧基查尔酮,10 MM DMSO 溶液 |
| 英文名称 | 4'-METHOXYCHALCONE |
| 英文同义词 | 4'-METHOXYCHALCONE;METHOXYCHALCONE, 4'-;(E)-1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE;RARECHEM AM UC 0609;2-BENZYLIDENE-4'-METHOXYACETOPHENONE;1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE;alpha-styryl p-anisyl ketone;4'-METHOXYCHALCONE 97% |
| CAS号 | 959-23-9 |
| 分子式 | C16H14O2 |
| 分子量 | 238.28 |
| EINECS号 | 213-495-5 |
| 相关类别 | 植物提取物;标准品;Chalcones;C15 to C38;Carbonyl Compounds;Ketones |
| Mol文件 | 959-23-9.mol |
| 结构式 |  |
4'-甲氧基查耳酮 性质
| 熔点 | 101-103 °C(lit.) |
|---|---|
| 沸点 | 397.5±42.0 °C(Predicted) |
| 密度 | 1.114±0.06 g/cm3(Predicted) |
| 储存条件 | Storage temp. 2-8°C |
| 形态 | 固体 |
| 颜色 | 白色至浅黄色 |
| 水溶解性 | Soluble in dichloromethane and methanol. Insoluble in water. |
| BRN | 644640 |
| 化妆品成分功效 | ANTIOXIDANT BLEACHING SKIN CONDITIONING |
| InChI | InChI=1S/C16H14O2/c1-18-15-10-8-14(9-11-15)16(17)12-7-13-5-3-2-4-6-13/h2-12H,1H3 |
| InChIKey | KJHHAPASNNVTSN-UHFFFAOYSA-N |
| SMILES | C(C1=CC=C(OC)C=C1)(=O)C=CC1=CC=CC=C1 |
| LogP | 4.180 (est) |
| CAS 数据库 | 959-23-9(CAS DataBase Reference) |
4'-Methoxychalcone存在于柑橘属植物中，是一种查耳酮衍生物，具有多种药理活性，如抗肿瘤和消炎活性。
PPARγ
4'-Methoxychalcone (5 μM; 8 days) markedly increases the mRNA expression of adipogenic genes during adipocyte differentiation, PPARγ, aP2, FAS, adiponectin and GluT 4. 4'-Methoxychalcone (5 μM; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells. 4'-Methoxychalcone (5 μM; 0-8 days) causes an increase in PPARγ expression during differentiation, while C/EBPβ protein expression is relatively unaffected.
RT-PCR
| Cell Line: | Preadipocyte 3T3-L1 cells |
| Concentration: | 5 μM |
| Incubation Time: | 0 day; 2 days; 4 days; 6 days; 8 days |
| Result: | Increased the mRNA expression of all adipogenic genes, except GluT1 in adipocyte. |
Western Blot Analysis
| Cell Line: | Preadipocyte 3T3-L1 cells |
| Concentration: | 5 μM |
| Incubation Time: | 8 days |
| Result: | Increased PPARγ expression in adipocyte. |
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