[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol

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[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol manufacturers

  • OUL245
  • OUL245 pictures
  • $1520.00
  • 2026-05-11
  • CAS:1023814-45-0
  • Purity:
  • Supply Ability: 10g
[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol Basic information
Product Name:[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol
Synonyms:[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol;1,2,4-Triazolo[3,4-b]benzothiazol-7-ol;OUL245
CAS:1023814-45-0
MF:C8H5N3OS
MW:191.21
EINECS:
Product Categories:
Mol File:1023814-45-0.mol
[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol Structure
[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol Chemical Properties
Melting point 284-286 °C
density 1.77±0.1 g/cm3(Predicted)
pka7.55±0.30(Predicted)
Safety Information
MSDS Information
[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol Usage And Synthesis
UsesOUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM[1].
IC 50PARP2: 44 nM (IC50); PARP-1: 570 nM (IC50); PARP3: 8.8 μM (IC50); PARP4: 6.0 μM (IC50); TNKS1: 1.6 μM (IC50); TNKS2: 370 μM (IC50); PARP10: 2.9 μM (IC50); PARP14: 6.7 μM (IC50); PARP15: 2.0 μM (IC50)
References[1] Murthy S, et al. [1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J Med Chem. 2023 Jan 4. DOI:10.1021/acs.jmedchem.2c01460
[1,2,4]triazolo[3,4-b][1,3]benzothiazol-7-ol Preparation Products And Raw materials
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