N-辛酰基-D-神经鞘氨醇
| 中文名称 | N-辛酰基-D-神经鞘氨醇 |
|---|---|
| 中文同义词 | N-辛酰基-D-神经鞘氨醇;N-辛酰神经鞘氨醇;N-[(1S,2R,3E)-2-羟基-1-(羟基甲基)-3-十七碳烯-1-基]-辛酰胺;N-辛酰基-D-赤型鞘氨醇;N-[(1S,2R,3E)-2-羟基-1-(羟甲基)-3-十七碳烯-1-基]-辛酰胺;C-8神经酰胺;N-辛酰基鞘氨醇;C8 CERAMIDE,BIOLOGICALLY ACTIVE CERAMIDE ANALOG |
| 英文名称 | C8 CERAMIDE |
| 英文同义词 | N-OCTANOYLSPHINGOSINE, D-ERYTHRO;N-OCTANOYL-D-ERYTHRO-SPHINGOSINE;N-OCTANOYL-D-SPHINGOSINE;N-OCTANOYLSPHINGOSINE;D-erythro-N-Octanoylsphingosine;N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl]Octanamide;N-Octanoyl-C18-sphingosine;N-Octanoyl-D-erythr |
| CAS号 | 74713-59-0 |
| 分子式 | C26H51NO3 |
| 分子量 | 425.69 |
| EINECS号 | |
| 相关类别 | 脂类;生化试剂;小分子;Mixed Fatty Acids;Activators;Fatty Acid Derivatives & Lipids;Glycerols;Inhibitors;Protein Kinase Inhibitors and Activators |
| Mol文件 | 74713-59-0.mol |
| 结构式 |  |
N-辛酰基-D-神经鞘氨醇 性质
| 熔点 | 68-70°C |
|---|---|
| 沸点 | 541.37°C (rough estimate) |
| 密度 | 0.9974 (rough estimate) |
| 折射率 | 1.6000 (estimate) |
| 储存条件 | −20°C |
| 溶解度 | 可溶于DMSO或乙醇：可溶 |
| 形态 | 蜡状固体 |
| 颜色 | 白色 |
| 稳定性 | 对温度敏感 |
| InChIKey | APDLCSPGWPLYEQ-WRBRXSDHSA-N |
| SMILES | C(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)(=O)CCCCCCC |
| CAS 数据库 | 74713-59-0(CAS DataBase Reference) |
|
PKC
|
apoptosis
|
autophagy
|
C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes.
C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells.
C8-ceramide may increase the endogenous ROS level (10-30 µM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 µM; 24 hours), and consequently triggering the apoptosis (10-50 µM; 48 hours) of NSCLC H1299 cells.
Cell Viability Assay
| Cell Line: | CALO cells, INBL cells, HeLa cells |
| Concentration: | 3 μM |
| Incubation Time: | 48 hours |
| Result: | Markedly reduced the tumor cell number. |
Cell Proliferation Assay
| Cell Line: | H1299 cells |
| Concentration: | 10 µM, 20 µM, 30 µM, 40 µM, 50 µM |
| Incubation Time: | 24 hours |
| Result: | Decreased the rate of cellular proliferation in a dose-dependent manner, with an IC 50 of 22.9 µM. |
Cell Cycle Analysis
| Cell Line: | H1299 cells |
| Concentration: | 10 µM, 20 µM, 30 µM, 40 µM, 50 µM |
| Incubation Time: | 24 hours |
| Result: | Caused the G1 arrest. |
Apoptosis Analysis
| Cell Line: | H1299 cells |
| Concentration: | 10 µM, 20 µM, 30 µM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Increased the level of cleaved caspase-3. |
C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8
+
and CD4
+
T cell responses to viral infections in virus infected mice.
| Animal Model: | C57BL/6 mice, with lymphocytic choriomeningitis virus infected |
| Dosage: | 0.1 mg/kg |
| Administration: | Intranasal administration |
| Result: | Increased the CD8 + T cell response to influenza in the lungs. |
安全信息
| 安全说明 | 24/25 |
|---|---|
| WGK Germany | 3 |
| 海关编码 | 29225000 |
| 提供商 | 语言 |
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英文
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-108391 | N-辛酰基-D-神经鞘氨醇 C8-Ceramide | 74713-59-0 | 5mg | 950元 |
| 2025/05/22 | HY-108391 | N-辛酰基-D-神经鞘氨醇 C8-Ceramide | 10 mM * 1 mLin DMSO | 1045元 |