| Company Name: |
InvivoChem |
| Tel: |
13549236410 |
| Email: |
sales@invivochem.cn |
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| | HSD-016 Basic information |
| Product Name: | HSD-016 | | Synonyms: | HSD-016;Benzenemethanol, 3-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-α-methyl-α-(trifluoromethyl)-, (αR)-;(2R)-1,1,1-Trifluoro-2-[3-[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonylphenyl]propan-2-ol | | CAS: | 946396-92-5 | | MF: | C21H21F7N2O3S | | MW: | 514.46 | | EINECS: | | | Product Categories: | | | Mol File: | 946396-92-5.mol |  |
| | HSD-016 Chemical Properties |
| Melting point | 102-104 °C | | Boiling point | 563.9±60.0 °C(Predicted) | | density | 1.421±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (194.38 mM; Need ultrasonic) | | pka | 11.60±0.15(Predicted) | | form | Solid | | color | White to off-white |
| | HSD-016 Usage And Synthesis |
| Uses | HSD-016 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 values of 11, 1 and 8 nM against human, mouse and rat 11β-HSD1, respectively. HSD-016 can be used for type 2 diabetes research[1]. | | References | [1] Wan ZK, et al. Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016. J Org Chem. 2011 Sep 2;76(17):7048-55. DOI:10.1021/jo200958a |
| | HSD-016 Preparation Products And Raw materials |
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