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| | Adiporon hydrochloride Basic information |
| Product Name: | Adiporon hydrochloride | | Synonyms: | 2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride;AdipoRon hcl;Adiporon hydrochloride | | CAS: | 1781835-20-8 | | MF: | C27H29ClN2O3 | | MW: | 464.99 | | EINECS: | | | Product Categories: | | | Mol File: | 1781835-20-8.mol |  |
| | Adiporon hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | Adiporon hydrochloride Usage And Synthesis |
| Uses | AdipoRon Hydrochloride is the hydrochloride salt of AdipoRon (A291670), which is an AdipoR agonist and activates AMPK and PPAR-α pathways in the muscle and liver. AdipoRon is a promising therapeutic approach for the treatment of obesity-related diseases such as type 2 diabetes. | | in vivo | AdipoRon (50 mg/kg, i.v.) cuases significant phosphorylation of AMPK in skeletal muscle and liver of wild-type mice but not Adipor1 / Adipor2 / double-knockout mice[1]. AdipoRon (0.02, 0.1, and 0.5 mg/kg, i.g.) alleviates D-GalN induced hepatotoxicity in mice, and prevents hepatic architecture distortion against D-GalN challenge. The hepatoprotective potential of AdipoRon is particularly evident in higher dosages (0.1 and 0.5 mg/kg)[2]. Enhanced cardiomyocyte apoptosis in APN-deficient mice is rescued by AdipoRon (50 mg/kg, p.o.) administration. Antiapoptotic effect of AdipoRon is attenuated but not lost in AMPK-DN mice[3]. | | storage | Desiccate at RT |
| | Adiporon hydrochloride Preparation Products And Raw materials |
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