- Gramine
-
- $122.00
-
2026-07-03
- CAS:87-52-5
- Min. Order: 1KG
- Purity: 99%
- Gramine
-
- $79.00
-
2026-06-02
- CAS:87-52-5
- Purity: 99.95%
- Supply Ability: 10g
- Gramine
-
-
2023-02-24
- CAS:87-52-5
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
|
| | Gramine Basic information |
| | Gramine Chemical Properties |
| Melting point | 132-134 °C (lit.) | | Boiling point | 295.23°C (rough estimate) | | density | 1.0715 (rough estimate) | | refractive index | 1.5500 (estimate) | | Fp | 167 °C | | storage temp. | Refrigerator (+4°C) | | solubility | almost transparency in Methanol | | pka | 17.00±0.30(Predicted) | | form | Powder | | color | Beige | | Water Solubility | PRACTICALLY INSOLUBLE | | Merck | 14,4533 | | BRN | 140521 | | InChI | 1S/C11H14N2/c1-13(2)8-9-7-12-11-6-4-3-5-10(9)11/h3-7,12H,8H2,1-2H3 | | InChIKey | OCDGBSUVYYVKQZ-UHFFFAOYSA-N | | SMILES | CN(C)Cc1c[nH]c2ccccc12 | | LogP | 2.177 (est) | | CAS DataBase Reference | 87-52-5(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-Indole-3-methanamine, N,N-dimethyl-(87-52-5) | | EPA Substance Registry System | 1H-Indole-3-methanamine, N,N-dimethyl- (87-52-5) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 45-36/37/39-26 | | WGK Germany | 3 | | RTECS | NL7525000 | | TSCA | TSCA listed | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Oral |
| | Gramine Usage And Synthesis |
| Chemical Properties | 3-(Dimethylaminomethyl)indole [87-52-5], gramine, C11H14N2, Mr 174.25, mp 138 – 139 ℃, forms colorless needles. The compound is soluble in ethanol, diethyl ether, and chloroform and insoluble in water. It can be synthesized from indole by the Mannich reaction with dimethyl-amine and formaldehyde. Gramine is used to synthesize D,L-tryptophan, the plant growth regulators indole-3-acetic acid and indole-3-butanoic acid as well as the intermediate tryptamine. | | Uses | Reactant for preparation of:
- Dopamine D2 receptor antagonists
- Anti-malarial drugs
- 5-indolyl-Mannich bases
- Proliferation inhibitors
- Inhibitors of human mast cell chymase
- Preparation of DL-tryptophan
- Potential detoxification inhibitors of the crucifer phytoalexin brassinin
- 3-vinylindoles
- Serotonin 5-HT6 receptor ligand templates
- Selective protein kinase c delta (PKCδ) down regulators
| | Definition | ChEBI: Gramine is an aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3. It has a role as a plant metabolite, a serotonergic antagonist, an antiviral agent and an antibacterial agent. It is an aminoalkylindole, an indole alkaloid and a tertiary amino compound. It is a conjugate base of a gramine(1+). | | General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | | storage | Room temperature | | Purification Methods | Crystallise gramine from diethyl ether, ethanol or acetone. It sublimes at 59o/0.001mm. The hydrochloride crystallises from EtOH/Et2O with m 190.5-191.0o(dec). [Culvenor et al. Aust J Chem 17 1301 1964, Beilstein 22 III/IV 4302, 22/10 V 25.] |
| | Gramine Preparation Products And Raw materials |
|