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NBI 27914 hydrochloride manufacturers
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| | NBI 27914 hydrochloride Basic information |
| Product Name: | NBI 27914 hydrochloride | | Synonyms: | NBI 27914 hydrochloride,NBI27914 hydrochloride;4,6-Pyrimidinediamine, 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)-, hydrochloride (1:1) | | CAS: | 1215766-76-9 | | MF: | C18H20Cl4N4.ClH | | MW: | 470.65 | | EINECS: | | | Product Categories: | | | Mol File: | 1215766-76-9.mol |  |
| | NBI 27914 hydrochloride Chemical Properties |
| storage temp. | Store at RT | | solubility | Soluble to 100 mM in ethanol and to 100 mM in DMSO | | form | Powder | | color | White to off-white |
| | NBI 27914 hydrochloride Usage And Synthesis |
| Uses | NBI 27914 Hydrochloride is a selective non-peptide corticotropin-releasing factor 1 (CRF1) antagonist. Shown to block behavioral seizures in vivo. | | in vivo | NBI 27914 (3~30 mg/kg; i.p.) hydrochloride attenuates the referred abdominal pain at the highest dose tested, it is efficacious both 4 and 24 h post-indomethacin dosing[1].
NBI 27914 (1~10 mg/kg; i.p.) hydrochloride dose dependently attenuates Freund's Complete Adjuvant-induced mechanical hyperalgesia. NBI 27914 (10 mg/kg) hydrochloride reverses the thermal hyperalgesia. NBI 27914 hydrochloride attenuates spinal nerve ligation-induced mechanical hyperalgesia and tactile allodynia with minimal effective doses equal to 5 and 10 mg/kg, respectively[1]. The higher doses of NBI 27914 hydrochloride blocks the behavioral seizures and prevents epileptic discharges in concurrent electroencephalograms recorded from the amygdala[2]. | Animal Model: | Male CD-1 mice (20~25 g)[1] | | Dosage: | 3~30 mg/kg | | Administration: | I.p. | | Result: | Attenuated the referred abdominal pain at the highest dose tested, it was efficacious both 4 and 24 h post-indomethacin dosing.
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| | IC 50 | CRFR1 | | storage | Store at RT |
| | NBI 27914 hydrochloride Preparation Products And Raw materials |
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