马尿酸乌洛托品
| 中文名称 | 马尿酸乌洛托品 |
|---|---|
| 中文同义词 | 马尿酸乌洛托品;环六亚甲基四胺 N-苯甲酰甘氨酸盐;马尿酸孟德立胺;马尿酸乌洛托 USP标准品;1,3,5,7-四氮杂金刚烷 苯甲酰基甘氨酸盐;乌洛托品马尿酸盐;马尿酸亚甲胺 |
| 英文名称 | Methenamine hippurate |
| 英文同义词 | 1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane, compd. with N-benzoylglycine (1:1);N-benzoylglycine, compound with 1,3,5,7-tetraazatricyclo[3.3.1.13,7]decane (1:1);METHENAMINEHIPPURATE,USP;N-Benzoylglycine 1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane (1:1);Hexamethylentetramine monohippurate;Methenamine hippurate;Methinamine hippurate(USP);glycine,n-benzoyl-,compd.with1,3,5,7-tetraazatricyclo(3.3.1.1(sup3,7))de |
| CAS号 | 5714-73-8 |
| 分子式 | C15H21N5O3 |
| 分子量 | 319.37 |
| EINECS号 | 227-206-5 |
| 相关类别 | 其他原料药;有机化工原料;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 5714-73-8.mol |
| 结构式 |  |
马尿酸乌洛托品 性质
| 熔点 | 89-95°C |
|---|---|
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 水溶解性 | H2O: 2mg/mL, clear |
| InChI | 1S/C9H9NO3.C6H12N4/c11-8(12)6-10-9(13)7-4-2-1-3-5-7;1-7-2-9-4-8(1)5-10(3-7)6-9/h1-5H,6H2,(H,10,13)(H,11,12);1-6H2 |
| InChIKey | ROAIXOJGRFKICW-UHFFFAOYSA-N |
| SMILES | OC(CNC(C1=CC=CC=C1)=O)=O.N2(CN(C3)C4)CN3CN4C2 |
马尿酸乌洛托品作为防治尿路感染的抗生素替代药物具有深远意义，它能降低抗生素使用，减少细菌耐药。Methenamine Hippurate是methenamine的马草酸盐形式，是一种前药和惰性弱碱，在酸性尿液中会水解成甲醛。Methenamine Hippurate是Hiprex药物的成分，具有抗菌活性。
Methenamine hippurate is a urinary antibacterial agent which releases formaldehyde and is excreted in the urine. Methenamine hippurate has a demonstrable activity in vitro at pH 5 to 6 against Escherichia coli , Staphylococcus aureus , Aerobacter aeroaenes , Pseudomonas aeruginosa and Proteus vulgaris , and a wide range of action against Klebsiella pneumoniae , Ps. aeruginosa , E. coli , Staph. aureus and Streptococcus haemolytic at pH of 7.4. This action is more effective than that of Methenamine alone, of Hippuric acid alone or of Sulphadiazine.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 海关编码 | 2933690000 |
| 存储类别 | 11 - 可燃固体 |