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PNU-282987 S enantiomer hydrochloride manufacturers
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| | PNU-282987 S enantiomer hydrochloride Basic information |
| Product Name: | PNU-282987 S enantiomer hydrochloride | | Synonyms: | PNU-282987 S enantiomer hydrochloride;(S)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride;(S)-PNU-282987 HCl;PNU282987 S enantiomer hydrochloride,PNU 282987 S enantiomer hydrochloride;(S)-PNU-282987 hydrochloride;PNU-282987 Impurity 2 Hydrochloride | | CAS: | 128311-08-0 | | MF: | C14H18Cl2N2O | | MW: | 301.21 | | EINECS: | | | Product Categories: | | | Mol File: | 128311-08-0.mol |  |
| | PNU-282987 S enantiomer hydrochloride Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| | PNU-282987 S enantiomer hydrochloride Usage And Synthesis |
| Uses | (S)-PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1]. | | in vivo | PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner[1]. | | References | [1] Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8. DOI:10.1021/jm049363q |
| | PNU-282987 S enantiomer hydrochloride Preparation Products And Raw materials |
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