| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- PNU-74654
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- $51.00
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2026-09-10
- CAS:113906-27-7
- Purity: 97.27%
- Supply Ability: 10g
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| | 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Basic information |
| Product Name: | 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide | | Synonyms: | 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide;PNU 74654;Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide;PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide;PNU74654; PNU 74654;CS-2563;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;PNU 74654, Wnt signaling pathway blocker | | CAS: | 113906-27-7 | | MF: | C19H16N2O3 | | MW: | 320.34 | | EINECS: | | | Product Categories: | | | Mol File: | 113906-27-7.mol | ![2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Structure](CAS/20181012/GIF/113906-27-7.gif) |
| | 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Chemical Properties |
| density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | solid | | pka | 12.12±0.46(Predicted) | | color | white to off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | | InChI | 1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+ | | InChIKey | JJEDWBQZCRESJL-DEDYPNTBSA-N | | SMILES | Cc1ccc(\C=N\NC(=O)c2ccccc2Oc3ccccc3)o1 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Usage And Synthesis |
| Description | PNU 75654 (113906-27-7) disrupts the Wnt signaling pathway via inhibition of the interaction (KD50= 450 nM) between β-catenin and T cell factor 4 (Tcf4). | | Uses | PNU 74654 is a β-catenin inhibitor which inhibits interactions between β-catenin and transcription factor T-cell factor 4 (Tcf4) thus disrupting the Wnt signal transduction pathway. | | Uses | PNU-74654 has been used:
- as a β-catenin signaling inhibitor to study its effects on the funnel cartilage differentiation in Sepia sp. embryos
- as a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines
- as a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells
| | Biochem/physiol Actions | PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF. | | storage | +4°C | | References | [1] JEAN-YVES TROSSET. Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.[J]. Proteins-Structure Function and Bioinformatics, 2006, 64 1: 60-67. DOI:10.1002/prot.20955 |
| | 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Preparation Products And Raw materials |
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