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| | Arylsulfonamide 64B Basic information |
| Product Name: | Arylsulfonamide 64B | | Synonyms: | Arylsulfonamide 64B;Benzenesulfonamide, N-cyclobutyl-N-[(2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl]-3,4-dimethoxy- | | CAS: | 1342890-83-8 | | MF: | C23H28N2O5S | | MW: | 444.54 | | EINECS: | | | Product Categories: | | | Mol File: | 1342890-83-8.mol |  |
| | Arylsulfonamide 64B Chemical Properties |
| Boiling point | 599.7±60.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | pka | 3.19±0.40(Predicted) |
| | Arylsulfonamide 64B Usage And Synthesis |
| Uses | Arylsulfonamide 64B (HIF inhibitor 64B) is an inhibitor of the hypoxia-induced factor (HIF). Arylsulfonamide 64B inhibits hypoxia/HIF-induced expression of c-Met and CXCR4 and reduces primary tumor growth and metastasis of uveal melanoma mouse model[1]. | | References | [1] Dong L, Y, et al. Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma. Clin Cancer Res. 2019;25(7):2206-2218. DOI:10.1158/1078-0432.CCR-18-1368 |
| | Arylsulfonamide 64B Preparation Products And Raw materials |
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