9-Bromo-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline manufacturers
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| | 9-Bromo-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline Basic information |
| Product Name: | 9-Bromo-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline | | Synonyms: | 9-BROMO-JULOLIDINE;4-BROMO-JULOLIDINE;1H,5H-Benzo[ij]quinolizine, 9-bromo-2,3,6,7-tetrahydro-;9-Bromo-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline;9-Bromo-2,3,6,7-tetrahydro-1h,5h-pyrido[3,2,1-ij]quinolone;9-Bromo-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline | | CAS: | 70173-54-5 | | MF: | C12H14BrN | | MW: | 252.15 | | EINECS: | | | Product Categories: | Quinoline&Isoquinoline | | Mol File: | 70173-54-5.mol | ![9-Bromo-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline Structure](CAS/GIF/70173-54-5.gif) |
| | 9-Bromo-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline Chemical Properties |
| Melting point | 36.5 °C | | Boiling point | 135.0-136.5 °C(Press: 0.15 Torr) | | density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 5.61±0.20(Predicted) | | Appearance | Brown to reddish brown <36.5°C Solid,>36.5°C Liquid | | CAS DataBase Reference | 70173-54-5(CAS DataBase Reference) |
| | 9-Bromo-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline Usage And Synthesis |
| Chemical Properties | White Crystalline | | Synthesis | The general procedure for the synthesis of 9-bromo-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline from julolidine: julolidine (675 mg, 3.90 mmol) and N-bromosuccinimide (832 mg, 4.68 mmol) were dissolved in 10 mL of N,N-dimethylformamide (DMF), and the reaction was stirred at room temperature for 5 hours. After completion of the reaction, the crude product was purified by silica gel column chromatography (eluent: hexane/dichloromethane, 3:1, v/v) to afford the target compound 9-bromo-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline (786 mg, 80% yield) as an oil. The structure of the product was confirmed by the following characterization: 1H NMR (500 MHz, CDCl3) δ/ppm: 6.87 (s, 2H), 3.10 (t, 4H, J=5.50 Hz), 2.70 (t, 4H, J=6.35 Hz), 1.94 (m, 4H); 13C NMR (500 MHz, CDCl3) δ/ppm: 142.0 ,129.3,123.7,107.3,50.0,27.6,21.9; IR (KBr, cm-1): 3045,2935,2836,1581,1506,1462,1446,1310; high-resolution mass spectrometry (TOFMS-EI) m/z: calculated value C12H14NBr [M]+ 251.0310 , measured value 251.0309. | | References | [1] Chemical and Pharmaceutical Bulletin, 1984, vol. 32, # 5, p. 1770 - 1779
[2] Canadian Journal of Chemistry, 2009, vol. 87, # 2, p. 440 - 447
[3] Journal of Organic Chemistry, 2011, vol. 76, # 22, p. 9391 - 9408
[4] Dyes and Pigments, 2013, vol. 99, # 3, p. 653 - 660
[5] European Journal of Organic Chemistry, 2011, # 30, p. 6100 - 6109 |
| | 9-Bromo-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline Preparation Products And Raw materials |
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