| Company Name: |
SHANG FLUORO Gold |
| Tel: |
021-65170832 15601903708 |
| Email: |
qinba_1@163.com |
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| | Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Basic information | | Synthesis |
| | Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Chemical Properties |
| Hazard Codes | C,Xi | | Risk Statements | 10-34 | | Safety Statements | 26-36/37/39-45-16 | | RIDADR | UN 2920 8/PG 2 | | WGK Germany | 3 | | F | 10-21 | | Hazard Note | Irritant | | TSCA | No | | HazardClass | 3.2 | | PackingGroup | III | | HS Code | 29159000 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Flam. Liq. 3
Skin Corr. 1B |
| | Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Usage And Synthesis |
| Synthesis | 
Equip a 1000 mL oven-dried three-necked round-bottom flask with a magnetic stir bar, an attached constant-pressure funnel, and a gas outlet. Connect the gas outlet to an empty 500 mL spare trap, which is then connected to the outlet of an inverted glass funnel located directly above a 1000 mL beaker containing 120 g NaOH in 600 mL of water. Add anhydrous methanol (160 g) to the flask. Add tetrafluoroethane-β-sulfonyl lactone (440 g) dropwise to the mixture through a feeding funnel with stirring. Cool the mixture in an ice bath for 3 hours. After the addition is complete, gradually heat the reaction mixture to room temperature. Stir the mixture overnight at room temperature. After purging with nitrogen for 1 hour to completely remove residual HF from the system, the resulting reaction mixture was washed with water (2 × 400 mL) and brine (2 × 400 mL) to remove residual methanol. The organic phase was collected and dried over anhydrous sodium sulfate. After filtration, the crude product was purified by distillation. | | Chemical Properties | clear colorless to yellow liquid | | Uses | Efficient reagent for the trifluoromethylation of aryls and difluorocyclopropanation of alkenes. | | Uses | Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate is a useful reagent for the trifluoromethylation of alkyl halides. It is also broadly applicable reagent for perfluoroalkylations for aryl iodides and bromides. | | reaction suitability | reaction type: click chemistry |
| | Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Preparation Products And Raw materials |
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