螺哌丙苯
| 中文名称 | 螺哌丙苯 |
|---|---|
| 中文同义词 | 螺拉米特;螺哌丙苯;AMI-193,D2样拮抗剂;螺拉米特,10 MM DMSO 溶液;Spiramide #天然产物 HY-100971;Spiramide #天然产物 HY-100971 |
| 英文名称 | AMI-193 |
| 英文同义词 | 8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE;AMI-193;1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one;Fluroxyspiramine;R 5808;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-;AMI-193, 10 mM in DMSO |
| CAS号 | 510-74-7 |
| 分子式 | C22H26FN3O2 |
| 分子量 | 383.46 |
| EINECS号 | |
| 相关类别 | Serotonin receptor |
| Mol文件 | 510-74-7.mol |
| 结构式 |  |
螺哌丙苯 性质
| 熔点 | 176 - 179°C |
|---|---|
| 储存条件 | Store at RT |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 白色固体。 |
| 颜色 | 灰白色至浅黄色 |
|
5-HT 2 Receptor 2 nM (Ki) |
D 2 Receptor 3 nM (Ki) |
5-HT 1A Receptor 50 nM (Ki) |
D 1 Receptor 2530 nM (Ki) |
5-HT 1C Receptor 4300 nM (Ki) |
Spiramide retains affinity for 5-HT 1A sites (K i =50 nM) and also binds at dopamine D2 sites (K i =3 nM), but possesses low affinity for dopamine D1 sites (K i =2530 nM).
AMI-193 (0.003-0.01 mg/kg; i.m.) dose-dependently decreases response rate in monkeys under a fixed-interval (FI) schedule of stimulus termination.
AMI-193 (0.003-0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine in drug-discrimination experiments.
AMI-193 (0.003-0.01 mg/kg; i.m.) reduces response rate under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion).
| Animal Model: | Adult male squirrel monkeys (850-1300 g) |
| Dosage: | 0.003, 0.01 mg/kg |
| Administration: | I.m. on Tuesday, Wednesday, and Thursday the following week |
| Result: |
Decreased the response rate.
The rate-decreasing effects were reversed by cocaine. |