3,3-Dimethoxybutan-2-one manufacturers
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| | 3,3-Dimethoxybutan-2-one Basic information |
| Product Name: | 3,3-Dimethoxybutan-2-one | | Synonyms: | 3,3-DIMETHOXY-2-BUTANONE;3,3-Dimethoxy-2-butanone,98%;3,3-Dimethoxybutan-2-one 98+%;3,3-DiMethoxy-2-butanon;3,5-dimethoxy-2-butanone;3,3-Dimethoxybutan-2-one;2-Butanone, 3,3-dimethoxy-;3,3-Dimethoxy-2-oxobutane | | CAS: | 21983-72-2 | | MF: | C6H12O3 | | MW: | 132.16 | | EINECS: | | | Product Categories: | Building Blocks;C3 to C6;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Aliphatics;C3 to C6;Carbonyl Compounds;Ketones | | Mol File: | 21983-72-2.mol |  |
| | 3,3-Dimethoxybutan-2-one Chemical Properties |
| Boiling point | 145-146 °C (lit.) | | density | 0.987 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.407(lit.) | | Fp | 113 °F | | storage temp. | Inert atmosphere,Room Temperature | | form | liquid | | color | Clear, colourless | | InChI | InChI=1S/C6H12O3/c1-5(7)6(2,8-3)9-4/h1-4H3 | | InChIKey | UFQBSPGKRRSATO-UHFFFAOYSA-N | | SMILES | CC(=O)C(OC)(OC)C |
| Hazard Codes | Xi,F | | Risk Statements | 10 | | Safety Statements | 16 | | RIDADR | UN 1224 3/PG 3 | | WGK Germany | 3 | | HazardClass | 3.2 | | PackingGroup | III | | HS Code | 29145000 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Flam. Liq. 3 |
| | 3,3-Dimethoxybutan-2-one Usage And Synthesis |
| Chemical Properties | Clear colorless liquid | | Uses | 3,3-Dimethoxybutan-2-one is used in preparation of 3-acetylpyrazole. | | Uses | 3,3-Dimethoxy-2-butanone may be used as starting reagent in the synthesis of 6-acety1-l,2-dihydro-2-oxo-3-pyridinecarboxylic acid. It may be used in the preparation of 4,4-dimethoxy-3-oxo-1-phenyl-1-pentene. | | General Description | 3,3-Dimethoxy-2-butanone is a biacetyl monoketal. | | Synthesis | The general procedure for the synthesis of 3,3-dimethoxy-2-butanone from 2,3-butanedione and trimethyl orthoformate was as follows: 2,3-butanedione (47.3 g, 0.55 mol) was added to a reaction flask equipped with a stirrer, and a mixture of trimethyl orthoformate (64.13 g, 0.605 mol) and p-toluenesulfonic acid (0.19 g) was slowly added dropwise at 15 °C. The reaction temperature was maintained at 15 °C and the reaction was continuously stirred for 7 h to ensure complete reaction. After completion of the reaction, potassium carbonate (1 g) was added to neutralize the reaction mixture and stirring was continued for 1 hour. Subsequently, distillation was carried out under reduced pressure at 100 mmHg and the crude product was collected. For further purification, the crude product was subjected to secondary distillation at 90 °C and 200 mbar. The yield of the final product was 83%. | | References | [1] Patent: CN107382687, 2017, A. Location in patent: Paragraph 0009; 0022-0033
[2] Journal of Organic Chemistry, 1995, vol. 60, # 25, p. 8204 - 8208
[3] Journal of Chemical Research, Miniprint, 1985, # 3, p. 925 - 945
[4] Tetrahedron, 2003, vol. 59, # 13, p. 2231 - 2239 |
| | 3,3-Dimethoxybutan-2-one Preparation Products And Raw materials |
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