Rifalazil manufacturers
- Rifalazil
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- $107.00
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2025-07-09
- CAS:129791-92-0
- Purity:
- Supply Ability: 10g
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| | Rifalazil Basic information |
| Product Name: | Rifalazil | | Synonyms: | RIFALAZIL;KRM 1648;3'-Hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin;1-Deoxy-1'-dehydro-1-oxo-3'-hydroxy-5'-[4-(2-methylpropyl)piperazino]rifamycin VIII;5,12-Dihydroxy-2,4-dimethyl-10-[4-(2-methyl-propyl)-l-piperazinyl]-2,7-[oxy(5-acetoxy-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxo-l,ll,13-pentadecatriene-l,15-diyl)imino]-6H-benzofuro[4,5-a]phenoxazine-l(2H),6-dione;Rifalazil USP/EP/BP;Rifamycin Impurity 43 | | CAS: | 129791-92-0 | | MF: | C51H64N4O13 | | MW: | 941.07 | | EINECS: | | | Product Categories: | | | Mol File: | 129791-92-0.mol |  |
| | Rifalazil Chemical Properties |
| Melting point | 195-200° (dec) | | Boiling point | 1065.6±65.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | 4°C, away from moisture | | solubility | DMSO: 8.33 mg/mL (8.85 mM) | | pka | 4.28±0.70(Predicted) | | form | Solid | | color | Blue to dark blue |
| | Rifalazil Usage And Synthesis |
| Uses | Antibacterial (antimycobacterial). | | Uses | Rifalazil has been used as a part of multi drug regimen in the treatment of tuberculosis. | | Definition | ChEBI: Rifalazil is a phenoxazine. | | in vivo | Rifalazil (oral gavage; 20, 25, and 150 mg/kg; 6-8 weeks) combines with isoniazid (INH) for 6 weeks or greater significantly reduced the number of mice per group in which M. tuberculosis is detected in both spleens and lungs compared to the reductions for the early and late controls. And the addition of Pyrazinamide (PZA) does not significantly improve RLZ-INH therapy at any time point[2]. | Animal Model: | Female CD-1 mice infected with 5.2 × 107viable mycobacteria[2] | | Dosage: | 20, 25, and 150 mg/kg; 6-8 weeks | | Administration: | Oral gavage | | Result: | Combined with isoniazid (INH) showed its potential for short-course treatment ofMycobacterium tuberculosisinfection. |
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| | Rifalazil Preparation Products And Raw materials |
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