6-(1H-Imidazol-1-yl)nicotinic acid manufacturers
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| | 6-(1H-Imidazol-1-yl)nicotinic acid Basic information |
| Product Name: | 6-(1H-Imidazol-1-yl)nicotinic acid | | Synonyms: | 6-IMIDAZOL-1-YL-NICOTINIC ACID;6-(1H-Imidazol-1-yl)pyridine-3-carboxylic acid, 1-(5-Carboxypyridin-2-yl)-1H-imidazole;6-imidazol-1-ylpyridine-3-carboxylic acid;6-(1H-imidazol-1-yl)-3-Pyridine carboxylic acid;6-(1H-Imidazol-1-yl);Pyridine,2,4-dichloro-, 1-oxide6-(1H-IMIDAZOL-1-YL)NICOTINIC ACID;3-Pyridinecarboxylic acid, 6-(1H-imidazol-1-yl)-;6-(1H-Imidazol-1-yl)nicotinicaci | | CAS: | 216955-75-8 | | MF: | C9H7N3O2 | | MW: | 189.17 | | EINECS: | | | Product Categories: | Carboxylic Acids;Pyridines;Carboxylic Acids | | Mol File: | 216955-75-8.mol |  |
| | 6-(1H-Imidazol-1-yl)nicotinic acid Chemical Properties |
| Melting point | >270° | | Boiling point | 442.5±30.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 2.92±0.10(Predicted) | | Appearance | White to off-white Solid |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2933399990 |
| | 6-(1H-Imidazol-1-yl)nicotinic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 6-(1H-imidazol-1-yl)nicotinic acid from 6-(1H-imidazol-1-yl)nicotinic acid methyl ester: In a round-bottomed flask, 6-(1H-imidazol-1-yl)nicotinic acid methyl ester (535 mg, 2.50 mmol), tetrahydrofuran (12 mL), sodium hydroxide (780 mg, 19.50 mmol), and methanol (10 mL) were added, and the reaction was conducted at 50°C for 3 h. The reaction was heated at 50°C for 3 h. Upon completion of the reaction, the reaction mixture was acidified with 1N hydrochloric acid and subsequently concentrated to dryness under reduced pressure. The resulting solid was suspended in a mixed solvent of methanol/dichloromethane, filtered and concentrated to give 6-(1H-imidazol-1-yl)nicotinic acid as a white solid (0.47 g, 68% yield).LCMS (m/z): 190.0 (M + 1). | | References | [1] Patent: WO2014/168824, 2014, A1. Location in patent: Page/Page column 39; 40
[2] Patent: WO2011/94890, 2011, A1. Location in patent: Page/Page column 130 |
| | 6-(1H-Imidazol-1-yl)nicotinic acid Preparation Products And Raw materials |
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