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(+/-)14,15-Epoxyeicosa-5z,8z,11z-trienoic acid

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(+/-)14,15-Epoxyeicosa-5z,8z,11z-trienoic acid Basic information
Product Name:(+/-)14,15-Epoxyeicosa-5z,8z,11z-trienoic acid
Synonyms:(+/-)14,15-EET;(+/-)14(15)-EPETRE;14(15)-EPETRE;(+/-)14(15)-EPOXY-5Z,8Z,11Z-EICOSATRIENOIC ACID;14,15-epoxy-5,8,11-eicosatrienoicacid;(5Z,8Z,11Z)-13-(3-pentyloxiran-2-yl)trideca-5,8,11-trienoic acid;(5Z,8Z,11Z)-13-[(2R,3S)-3-Pentyloxiranyl]-5,8,11-tridecatrienoic acid;(5Z,8Z,11Z,14R,15S)-14,15-Epoxy-5,8,11-icosatrienoic acid
CAS:81276-03-1
MF:C20H32O3
MW:320.47
EINECS:
Product Categories:
Mol File:81276-03-1.mol
(+/-)14,15-Epoxyeicosa-5z,8z,11z-trienoic acid Structure
(+/-)14,15-Epoxyeicosa-5z,8z,11z-trienoic acid Chemical Properties
Boiling point 464.5±33.0 °C(Predicted)
density 0.983±0.06 g/cm3(Predicted)
Fp 14 °C
storage temp. −20°C
pka4.78±0.10(Predicted)
form Liquid (Density: 0.983±0.06 g/cm3)
color Colorless to light yellow
Safety Information
Hazard Codes F,Xi
Risk Statements 11-36/37/38
Safety Statements 16-26-36-7
RIDADR UN 1170 3/PG 2
MSDS Information
(+/-)14,15-Epoxyeicosa-5z,8z,11z-trienoic acid Usage And Synthesis
UsesEpoxyeicosatrienoic Acid (EET) has antihypertensive and anti-inflammatory properties and play a role in the maintenance of renal vascular function. N,N''-dicyclohexylurea (DCU) increased release of 14,15-EET when the cells were stimulated with a calcium ionophore.Also, it is derived from Arachidonic Acid >97% (A765000), which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.
DefinitionChEBI: 14,15-Epoxy-5,8,11-eicosatrienoic acid is a long-chain fatty acid.
in vivo

14,15-Epoxyeicosatrienoic acid (0.3 mg/kg i.v.) inhibits platelet aggregation in mouse cerebral arterioles[2].
14,15-Epoxyeicosatrienoic acid (200 ng/ml) infusion into the hippocampus reversed Aβ deposition in the brains of 6-month-old male FAD mice[1].

IC 50Human Endogenous Metabolite
(+/-)14,15-Epoxyeicosa-5z,8z,11z-trienoic acid Preparation Products And Raw materials
Tag:(+/-)14,15-Epoxyeicosa-5z,8z,11z-trienoic acid(81276-03-1) Related Product Information
(+/-)-cis-14,15-Epoxy-5(Z),8(Z),11(Z)-eicosatrienoic acid Methyl-14(S),15(S)-epoxy-13(R)-hydroxy-5(Z),8(Z),11(Z)-eicosatrienoate (+/-)14,15-Epoxyeicosa-5z,8z,11z-trienoic acid Methyl 13(R)-hydroxy-14(S),15(S)-epoxy-5(Z),8(Z),11(Z)-eicosatrienoate 14(S),15(R)-Epoxy-(5Z,8Z,11Z)-eicosatrienoic acid (+/-)14(15)-Epetre methyl ester 14(R),15(S)-Epoxy-(5Z,8Z,11Z)-eicosatrienoic acid Methyl 13(S)-hydroxy-14(S),15(S)-epoxy-5(Z),8(Z),11(Z)-eicosatrienoate Methyl-14(S),15(S)-epoxy-13(S)-hydroxy-5(Z),8(Z),11(Z)-eicosatrienoate 2-(14,15-Epoxyeicosatrienoyl) glycerol