METHYL-2-METHYL-5-CARBOXYLICBENZOIC ACID manufacturers
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| | METHYL-2-METHYL-5-CARBOXYLICBENZOIC ACID Basic information |
| Product Name: | METHYL-2-METHYL-5-CARBOXYLICBENZOIC ACID | | Synonyms: | METHYL-2-METHYL-5-CARBOXYLICBENZOIC ACID;4-METHYL-3-(METHOXYCARBONYL)BENZOIC ACID;METHY-2-METHYL-5-CARBOXYLICBENZOIC ACID;3-(Methoxycarbonyl)-4-Methylbenzoic acid;3-(Methoxycarbonyl);1,3-Benzenedicarboxylic acid, 4-methyl-, 3-methyl ester | | CAS: | 167300-06-3 | | MF: | C10H10O4 | | MW: | 194.18 | | EINECS: | | | Product Categories: | | | Mol File: | 167300-06-3.mol |  |
| | METHYL-2-METHYL-5-CARBOXYLICBENZOIC ACID Chemical Properties |
| Boiling point | 349.9±30.0 °C(Predicted) | | density | 1.243±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.00±0.10(Predicted) | | Appearance | White to off-white Solid |
| | METHYL-2-METHYL-5-CARBOXYLICBENZOIC ACID Usage And Synthesis |
| Synthesis | Methyl 5-formyl-2-methylbenzoate (268 mg, 1.5 mmol) was used as starting material and dissolved in N,N-dimethylformamide (DMF, 5 mL). Subsequently, Oxone (1.110 g, 1.8 mmol) was added to the solution and the reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc, 10 mL) followed by 0.5 M aqueous hydrochloric acid (20 mL). The organic phase was separated, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 3-(methoxycarbonyl)-4-methylbenzoic acid as an off-white powder (247 mg, 1% yield). The structure of the product was confirmed by 1H NMR (500 MHz, DMSO-d6): δ 8.38 (d, J = 1.8 Hz, 1H), 8.01 (dd, J = 7.9, 1.9 Hz, 1H), 7.48 (d, J = 8.0 Hz, 1H), 3.86 (s, 3H), 2.59 (s, 3H). | | References | [1] Patent: WO2018/89433, 2018, A1. Location in patent: Paragraph 00317 |
| | METHYL-2-METHYL-5-CARBOXYLICBENZOIC ACID Preparation Products And Raw materials |
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