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| | E3 Ligase Ligand-Linker Conjugates 56 Basic information |
| Product Name: | E3 Ligase Ligand-Linker Conjugates 56 | | Synonyms: | E3 Ligase Ligand-Linker Conjugates 56;VHL Ligand-Linker Conjugates 15;(2S,4R)-N-[(2-{2-[4-(1,3-dioxolan-2-yl)phenoxy]ethoxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide | | CAS: | 2375564-62-6 | | MF: | C37H45FN4O8S | | MW: | 724.84 | | EINECS: | | | Product Categories: | | | Mol File: | 2375564-62-6.mol |  |
| | E3 Ligase Ligand-Linker Conjugates 56 Chemical Properties |
| Boiling point | 953.0±65.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | pka | 13.79±0.20(Predicted) |
| | E3 Ligase Ligand-Linker Conjugates 56 Usage And Synthesis |
| Uses | VHL Ligand-Linker Conjugates 15 incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 15 can be used to design PROTACs[1]. | | IC 50 | VHL | | References | [1] Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680. DOI:10.1038/s41589-019-0294-6 |
| | E3 Ligase Ligand-Linker Conjugates 56 Preparation Products And Raw materials |
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