Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)-

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Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)- manufacturers

  • GKI-1
  • GKI-1 pictures
  • $89.00
  • 2026-07-15
  • CAS:2444764-03-6
  • Purity: 99.96%
  • Supply Ability: 10g
  • GKI-1
  • GKI-1 pictures
  • $89.00
  • 2026-07-15
  • CAS:2444764-03-6
  • Purity: 99.96%
  • Supply Ability: 10g
Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)- Basic information
Product Name:Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)-
Synonyms:Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)-;GKI-1, 10 mM in DMSO
CAS:2444764-03-6
MF:C15H12ClN3
MW:269.73
EINECS:
Product Categories:
Mol File:2444764-03-6.mol
Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)- Structure
Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)- Chemical Properties
Boiling point 504.5±45.0 °C(Predicted)
density 1.320±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 200 mg/mL (741.48 mM)
pka13.93±0.50(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)- Usage And Synthesis
UsesGKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 μM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 μM, but only weakly affected PKA[1].
References[1] Ocasio CA, et al. A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget. 2016 Nov 1;7(44):71182-71197. DOI:10.18632/oncotarget.11511
Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)- Preparation Products And Raw materials
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