JMS-17-2 HYDROCHLORIDE
| 中文名称 | JMS-17-2 HYDROCHLORIDE |
|---|---|
| 中文同义词 | |
| 英文名称 | JMS 17-2 hydrochloride |
| 英文同义词 | JMS 17-2 hydrochloride |
| CAS号 | 2341841-07-2 |
| 分子式 | C25H27Cl2N3O |
| 分子量 | 456.41 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2341841-07-2.mol |
| 结构式 |  |
JMS-17-2 HYDROCHLORIDE 性质
| 溶解度 | 在 DMSO 中溶解度为 100 mM，在乙醇中溶解度为 50 mM |
|---|
JMS-17-2 hydrochloride 是一种有效的选择性 CX3CR1 拮抗剂，IC50 为 0.32 nM。JMS-17-2 hydrochloride 降低乳腺癌细胞的转移和定植。
IC50: 0.32 nM (CX3CR1)
JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice.
| Animal Model: | SCID mice (~25g) with MDA-231 xenograft |
| Dosage: | 10 mg/kg |
| Administration: | Aministered i.p.; twice a day for three weeks |
| Result: | Caused a dramatic reduction of tumors in both skeleton and visceral organs. |