JMS 17-2 hydrochloride

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JMS 17-2 hydrochloride Basic information
Product Name:JMS 17-2 hydrochloride
Synonyms:JMS 17-2 hydrochloride
CAS:2341841-07-2
MF:C25H27Cl2N3O
MW:456.41
EINECS:
Product Categories:
Mol File:2341841-07-2.mol
JMS 17-2 hydrochloride Structure
JMS 17-2 hydrochloride Chemical Properties
solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol
Safety Information
MSDS Information
JMS 17-2 hydrochloride Usage And Synthesis
UsesJMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells[1].
in vivo

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1].

Animal Model:SCID mice (~25g) with MDA-231 xenograft[1]
Dosage:10 mg/kg
Administration:Aministered i.p.; twice a day for three weeks
Result:Caused a dramatic reduction of tumors in both skeleton and visceral organs.
storageDesiccate at RT
References[1] Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27. DOI:10.1158/1541-7786.MCR-16-0013
JMS 17-2 hydrochloride Preparation Products And Raw materials
Tag:JMS 17-2 hydrochloride(2341841-07-2) Related Product Information
JMS 17-2 hydrochloride 5-(2-Aminoethyl)pyrrolo[1,2-a]quinoxalin-4(5h)-one Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]- 7-Chloropyrrolo[1,2-a]quinoxalin-4(5H)-one NA 1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-