1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-

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1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)- Suppliers list
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1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)- Basic information
Product Name:1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-
Synonyms:1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-;ONO-9780307
CAS:856691-44-6
MF:C30H35NO7
MW:521.6
EINECS:
Product Categories:
Mol File:856691-44-6.mol
1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)- Structure
1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)- Chemical Properties
Boiling point 725.5±60.0 °C(Predicted)
density 1.25±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 190 mg/mL (364.26 mM; Need ultrasonic)
pka4.25±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)- Usage And Synthesis
UsesONO-9780307 is a specific synthetic LPA1 (lysophosphatidic acid receptor 1) antagonist with an IC50 value of 2.7 nM[1].
Biological ActivityONO-9780307 is a specific synthetic LPA1 (lysophosphatidic acid receptor 1) antagonist with an IC50 value of 2.7 nM[1]. VT107 (0.1~10000 μM; LPA1-B103 and Vector-B103 cells) results in inhibition of Ca2+ mobilization[1].ONO-9780307 is used to solve the LPA1 crystal structure, binds to an orthosteric site in LPA1[1].
IC 50LPA1 Receptor: 2.7 nM (IC50)
References[1]. Mizuno H, et al. Lysophospholipid G protein-coupled receptor binding parameters as determined by backscattering interferometry. J Lipid Res. 2019;60(1):212-217.
1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)- Preparation Products And Raw materials
Tag:1H-Pyrrole-3-acetic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-(856691-44-6) Related Product Information
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