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1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)-

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1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:KRAS G12C inhibitor 14
CAS:2349393-95-7
Package:25mg;1890USD
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:KRAS G12C inhibitor 14
CAS:2349393-95-7
Purity:98% Package:$280.9/1mg;$710.9/5mg;$1150.9/10mg;Bulk package Remarks:98%
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:KRAS G12C inhibitor 14
CAS:2349393-95-7
Package:25mg;1890USD
Company Name: Suzhou Zhixin Biotechnology Co., Ltd.  
Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
Products Intro: Product Name:KRASG12Cinhibitor14
CAS:2349393-95-7
Purity:98%+ Package:1g;10g;100g
Company Name: Nantong Hanfang Biotechnology Co. , Ltd.  
Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Products Intro: Product Name:1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)-
CAS:2349393-95-7
Purity:98%+ Package:1g；5g；10g；100g; 1kg

1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- manufacturers
1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- Basic information
Product Name:1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)-
Synonyms:1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)-
CAS:2349393-95-7
MF:C24H19ClF2N4O3
MW:484.88
EINECS:
Product Categories:
Mol File:2349393-95-7.mol
1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- Structure
1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- Chemical Properties
Boiling point 733.1±60.0 °C(Predicted)
density 1.56±0.1 g/cm3(Predicted)
storage temp. Store at -20°C, protect from light, stored under nitrogen
solubility DMSO : 100 mg/mL (206.24 mM; Need ultrasonic)
form Solid
pka6.72±0.35(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- Usage And Synthesis
UsesKRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM[1].
Biological ActivityKRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM[1].
IC 50KRas G12C: 18 nM (IC50)
References[1]. Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1.
1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)- Preparation Products And Raw materials
Tag:1H-Pyrazino[1',2':4,5]pyrazino[2,3-c]quinolin-5(6H)-one, 11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-2,3,4,4a-tetrahydro-6-methyl-3-(1-oxo-2-propen-1-yl)-, (4aR)-(2349393-95-7) Related Product Information
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