| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:TH1760
CAS:2567914-01-4
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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2(3H)-Benzoxazolone, 6-[[4-(1H-indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]- manufacturers
- TH1760
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- $50.00 / 5mg
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2026-01-05
- CAS:2567914-01-4
- Min. Order:
- Purity: 97.31%
- Supply Ability: 10g
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| | 2(3H)-Benzoxazolone, 6-[[4-(1H-indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]- Basic information |
| | 2(3H)-Benzoxazolone, 6-[[4-(1H-indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]- Chemical Properties |
| density | 1.534±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (>25 mg/ml) | | form | solid | | pka | 8.55±0.70(Predicted) | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | SMILES | O=S(C1=CC(O2)=C(C=C1)NC2=O)(N3CCN(CC3)C(C4=CC5=C(C=C4)NC=C5)=O)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 2(3H)-Benzoxazolone, 6-[[4-(1H-indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]- Usage And Synthesis |
| Description | TH1760 (2567914-01-4) is a potent inhibitor (IC50 = 25 nM dGTP hydrolysis; 57 nM 6-thio-dGTP hydrolysis) of the NUDIX hydrolase NUDT15, an important enzyme involved in the hydrolysis thiopurine chemotherapeutics. It was selective against other human NUDIX proteins as well as a panel of 44 kinases and the Eurofins Cerep SafetyScreen44 panel. It was active in AML cell lines HL-60 and NB4 as well as HCT116 3-6 colorectal carcinoma cells and 697 B-ALL cells. | | Uses | TH1760 is an inhibitor of NUDIX-type 15 (NUDT15) with an IC50 value of 25 nM. TH1760 sensitizes cells to 6-thioguanine by enhancing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 enhances the anti-leukemia effect of thiopurine[1][2]. | | storage | Store at -20°C | | References | [1] SI MIN ZHANG. Development of a chemical probe against NUDT15[J]. Nature chemical biology, 2020, 16 10: 1120-1128. DOI:10.1038/s41589-020-0592-z |
| | 2(3H)-Benzoxazolone, 6-[[4-(1H-indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]- Preparation Products And Raw materials |
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