H-8 dihydrochloride manufacturers
- H-8 hydrochloride
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- $36.00
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2026-07-15
- CAS:113276-94-1
- Purity: 99.93%
- Supply Ability: 10g
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| | H-8 dihydrochloride Basic information |
| Product Name: | H-8 dihydrochloride | | Synonyms: | 5-IsoquinolinesulfonaMide,N-[2-(MethylaMino)ethyl]-, hydrochloride (1:2);H-8 HYDROCHLORIDE;N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL;N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, DI-HCL SALT;N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE DIHYDROCHLORIDE;N-(2-[METHYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE;N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE-5-SULFONAMIDE DIHYDROCHLORIDE;H-8 DIHYDROCHLORIDE POTENT INHIBITOR OF C | | CAS: | 113276-94-1 | | MF: | C12H17Cl2N3O2S | | MW: | 338.25 | | EINECS: | | | Product Categories: | | | Mol File: | 113276-94-1.mol |  |
| | H-8 dihydrochloride Chemical Properties |
| Melting point | 221-222℃ (methanol water ) | | storage temp. | 2-8°C | | solubility | ethanol: 25 mg/mL, clear, colorless | | form | Lyophilized | | color | White to Off-White | | Water Solubility | water: 10mg/mL | | InChI | InChI=1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H | | InChIKey | RJJLZYZEVNCZIW-UHFFFAOYSA-N | | SMILES | C12=CC=NC=C1C=CC=C2S(=O)(=O)NCCNC.Cl.Cl | | CAS DataBase Reference | 113276-94-1(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29334990 | | Storage Class | 11 - Combustible Solids |
| | H-8 dihydrochloride Usage And Synthesis |
| Description | The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 μM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC50 values of 47 and 6.2 μM, respectively. | | Chemical Properties | white to off-white crystalline solid | | Uses | Active inhibitor of cyclic-nucleotide-dependent protein kinases. | | Biochem/physiol Actions | cAMP and cGMP-dependent protein kinase inhibitor. | | References | [1] R A ENGH. Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.[J]. The Journal of Biological Chemistry, 1996, 271 42: 26157-26164. DOI: 10.1074/jbc.271.42.26157
[2] HIROYOSHI HIDAKA. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C[J]. Biochemistry Biochemistry, 1984, 23 21: 5036-5041. DOI: 10.1021/bi00316a032
[3] M HAGIWARA H H M Inagaki. Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase.[J]. Molecular Pharmacology, 1987, 31 5: 523-528.
[4] P RICKERT E L J L Corden. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases.[J]. Oncogene, 1999, 18 4: 1093-1102. DOI: 10.1038/sj.onc.1202399 |
| | H-8 dihydrochloride Preparation Products And Raw materials |
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