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5-nitro-2-(4-nitrophenyl)-1H-benzimidazole

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Products Intro: Product Name:5-nitro-2-(4-nitrophenyl)-1H-benzimidazole
CAS:1772-39-0
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CAS:1772-39-0
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Products Intro: Product Name:6-Nitro-2-(4-nitrophenyl)-1H-benzo[d]imidazole
CAS:1772-39-0
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CAS:1772-39-0
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5-nitro-2-(4-nitrophenyl)-1H-benzimidazole Basic information
Product Name:5-nitro-2-(4-nitrophenyl)-1H-benzimidazole
Synonyms:5-nitro-2-(4-nitrophenyl)-1H-benzimidazole;5-Nitro-2-(4-nitrophenyl)benziMidazole, 95%;5-Nitro-2-(4-nitrophenyl)-1H-benzoimidazole;MMP2-IN-2;6-Nitro-2-(4-nitrophenyl)-1H-benzo[d]imidazole;1H-Benzimidazole, 6-nitro-2-(4-nitrophenyl)-
CAS:1772-39-0
MF:C13H8N4O4
MW:284.23
EINECS:217-200-0
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Mol File:1772-39-0.mol
5-nitro-2-(4-nitrophenyl)-1H-benzimidazole Structure
5-nitro-2-(4-nitrophenyl)-1H-benzimidazole Chemical Properties
Melting point 300 °C
Boiling point 565.2±56.0 °C(Predicted)
density 1.544±0.06 g/cm3(Predicted)
form Solid
pka9.07±0.10(Predicted)
color Light brown to brown
Safety Information
MSDS Information
5-nitro-2-(4-nitrophenyl)-1H-benzimidazole Usage And Synthesis
DescriptionNSC-657186 is a novel selective non-zinc-binding MMP-2 inhibitor.
UsesMMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC50 values of 12, 23.3, and 25 μM, respectively[1].
IC 50MMP-2: 4.2 ± 0.2 μM (IC50); MMP13: 12 ± 7 μM (IC50); MMP-9: 23.3 ± 10. μM (IC50); MMP-8: 25 ± 10 μM (IC50)
References[1] Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28(3):115257. DOI:10.1016/j.bmc.2019.115257
5-nitro-2-(4-nitrophenyl)-1H-benzimidazole Preparation Products And Raw materials
Preparation Products2-(4-Aminophenyl)-1H-benzimidazol-5-amine
Tag:5-nitro-2-(4-nitrophenyl)-1H-benzimidazole(1772-39-0) Related Product Information
TIMTEC-BB SBB010040 4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE 2-(4-NITRO-PHENYL)-1H-IMIDAZOLE 4-(1H-IMIDAZOL-2-YL)-PHENYLAMINE 2-(4-Aminophenyl)-1H-benzimidazol-5-amine 5-nitro-2-(4-nitrophenyl)-1H-benzimidazole