4-METHYLPYRAZOLE HYDROCHLORIDE

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Company Name: Tianjin heowns Biochemical Technology Co., Ltd.  
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Company Name: Sigma-Aldrich  
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4-METHYLPYRAZOLE HYDROCHLORIDE manufacturers
4-METHYLPYRAZOLE HYDROCHLORIDE Basic information
Product Name:4-METHYLPYRAZOLE HYDROCHLORIDE
Synonyms:FOMEPIZOLE HYDROCHLORIDE;4-METHYLPYRAZOLE HYDROCHLORIDE;Fomepizole/FomepizolechlorideHCl;4-Methyl-1H-pyrazole hydrochloride;4-Methylpyrazole hydrochloride alcohol dehydrogenase inhibitor;Fomepizole HCl
CAS:56010-88-9
MF:C4H7ClN2
MW:118.56
EINECS:
Product Categories:
Mol File:56010-88-9.mol
4-METHYLPYRAZOLE HYDROCHLORIDE Structure
4-METHYLPYRAZOLE HYDROCHLORIDE Chemical Properties
Melting point 157-159 °C
storage temp. 2-8°C
solubility methanol: 100mg/mL, clear, colorless to yellow
form powder
color Purple to purplish red
biological sourcesynthetic (organic)
InChI1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H
InChIKeyPUCXJHNDMYZOHG-UHFFFAOYSA-N
SMILESCl.Cc1cn[nH]c1
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
ProviderLanguage
SigmaAldrich English
4-METHYLPYRAZOLE HYDROCHLORIDE Usage And Synthesis
Uses4-Methylpyrazole hydrochloride has been used:
  • as a cytochrome P450 2E1 inhibitor
  • as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells
  • to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells

Biochem/physiol Actions4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.
in vivo

Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice[4]

Animal Model:Male CD-1 mice weighing 18-25 g[4]
Dosage:25 mg/kg
Administration:IP; single dose
Result:Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50).
IC 50CYP2E1
4-METHYLPYRAZOLE HYDROCHLORIDE Preparation Products And Raw materials
Tag:4-METHYLPYRAZOLE HYDROCHLORIDE(56010-88-9) Related Product Information
5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE 5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXALDEHYDE (-)-QUINPIROLE HYDROCHLORIDE 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE Dichlorosulfophenyl-3-methylpyrazolone 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde 1-(4-CHLOROPHENYL)-5-PROPYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 4-Methylpyrazole ETHYL 1-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID 1-(3-CHLOROPHENYL)-5-(1H-PYRROL-1-YL)-1H-PYRAZOLE-4-CARBONITRILE 5-AMINO-1-(3-CHLORO-4-FLUOROPHENYL)-4-CYANOPYRAZOLE 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID HYDRAZIDE 4-METHYLPYRAZOLE HYDROCHLORIDE 5-AMINO-1-(2,4-DICHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE 5-CHLORO-3-[2-(DIMETHYLAMINO)-1-FORMYLVINYL]-1-PHENYL-1H-PYRAZOLE-4-CARBOXALDEHYDE