|
|
| | 4-Fluoroindole-2-carboxylic acid Basic information |
| | 4-Fluoroindole-2-carboxylic acid Chemical Properties |
| Melting point | 219-220 °C (decomp) | | Boiling point | 422.2±25.0 °C(Predicted) | | density | 1.510±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 4.32±0.30(Predicted) | | form | powder | | color | Pale yellow | | CAS DataBase Reference | 399-68-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2933998090 |
| | 4-Fluoroindole-2-carboxylic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 4-fluoroindole-2-carboxylic acid from the compound (CAS: 7593-91-1): 4.8 g (31 mmol) of compound 32 was dissolved in 60 mL of 4% NH4OH solution, which was subsequently added to a solution prepared from 52.45 g (188.7 mmol) of ferrous sulfate heptahydrate and 23 mL of concentrated NH4OH in 200 mL of water in a suspension of ferrous hydroxide. The reaction mixture was kept at boiling point for 5 minutes. Upon completion of the reaction, the resulting iron hydroxide precipitate was separated by filtration and washed repeatedly with dilute NH4OH and water. The filtrate was acidified with dilute HCl to a suitable pH and the precipitated solid was subsequently collected by filtration to afford 1.2 g (22% yield) of 4-fluoro-1H-indole-2-carboxylic acid (34) as a white solid. The resulting product could be used directly in the next step of the reaction without further purification. | | References | [1] Journal of Medicinal Chemistry, 1988, vol. 31, # 5, p. 944 - 948
[2] Patent: US2014/66453, 2014, A1. Location in patent: Paragraph 0184-0185 |
| | 4-Fluoroindole-2-carboxylic acid Preparation Products And Raw materials |
|