- 4-Fluoroindole
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2026-01-29
- CAS:387-43-9
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 300kg
- 4-Fluoroindole
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- $1.00
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2024-06-26
- CAS:387-43-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20t
- 4-Fluoroindole
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- $20.00
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2023-08-18
- CAS:387-43-9
- Min. Order: 1kg
- Purity: 99.99%
- Supply Ability: 50000tons
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| | 4-Fluoroindole Basic information |
| | 4-Fluoroindole Chemical Properties |
| Melting point | 30-32 °C(lit.) | | Boiling point | 90 °C0.4 mm Hg(lit.) | | density | 1.1203 (estimate) | | Fp | >110° | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | soluble in Methanol | | form | Crystalline Powder | | pka | 16.40±0.30(Predicted) | | color | Yellow to tan | | InChI | InChI=1S/C8H6FN/c9-7-2-1-3-8-6(7)4-5-10-8/h1-5,10H | | InChIKey | ZWKIJOPJWWZLDI-UHFFFAOYSA-N | | SMILES | N1C2=C(C(F)=CC=C2)C=C1 | | CAS DataBase Reference | 387-43-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29339900 |
| | 4-Fluoroindole Usage And Synthesis |
| Chemical Properties | Beige low melting solid | | Uses | Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators 1 Reactant for preparation of antifungal agents 2 Reactant for preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes 3 Reactant for preparation of Potent Selective Serotonin Reuptake Inhibitors 4 Reactant for preparation of Inhibitors of HIV-1 attachment 5 Reactant for preparation of monoamine reuptake inhibitors 6 Reactant for preparation of histone deacetylase (HDAC) inhibitors 7 Reactant for preparation of inhibitors of proliferation of human breast cancer cells. | | Synthesis | A suspension was prepared from 1-[2-(2-fluoro-6-nitrophenyl)vinyl]pyrrolidine (6 g, 25.42 mmol) in methanol (50 mL). To this suspension, Raney nickel (500 mg) was added and the hydrogenation reaction was carried out at atmospheric pressure at ambient temperature for 20 hours. After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was collected. The filtrate was concentrated under vacuum to afford the target product 4-fluoro-1H-indole (2.05 g, 60% yield) as a brown liquid. | | References | [1] Patent: WO2009/130481, 2009, A1. Location in patent: Page/Page column 149-150
[2] Patent: JP2016/204312, 2016, A. Location in patent: Paragraph 0026; 0071; 0076; 0079; 0085 |
| | 4-Fluoroindole Preparation Products And Raw materials |
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