| Company Name: |
BOC Sciences |
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16314854226 |
| Email: |
info@bocsci.com |
a-Hydroxy Tamoxifen manufacturers
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| | a-Hydroxy Tamoxifen Basic information |
| | a-Hydroxy Tamoxifen Chemical Properties |
| Melting point | 115-119°C | | Boiling point | 533.8±50.0 °C(Predicted) | | density | 1.094±0.06 g/cm3(Predicted) | | storage temp. | Amber Vial, -20°C Freezer | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 14.13±0.20(Predicted) | | form | Solid | | color | Pale Yellow to Pale Beige |
| | a-Hydroxy Tamoxifen Usage And Synthesis |
| Description | Tamoxifen is a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Although it is an antagonist of ER action in breast tissue, it acts as an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues. α-hydroxy Tamoxifen is a reactive metabolite of tamoxifen that is formed by the action of cytochrome P450 3A4 in human liver. It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma. | | Chemical Properties | Pale Yellow Solid | | Uses | A metabolite of the chemotherapeutic drug tamoxifen. Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Also active as an intramembranous inhibitor of lipid peroxidation. | | Uses | A metabolite of the chemotherapeutic drug Tamoxifen (T006000). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Also active as an intramembranous inhibitor of lipid peroxidation. | | Definition | ChEBI: Alpha-Hydroxytamoxifen is a stilbenoid. |
| | a-Hydroxy Tamoxifen Preparation Products And Raw materials |
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