氯苯氨啶
| 中文名称 | 氯苯氨啶 |
|---|---|
| 中文同义词 | 5-(3,4-二氯苯基)-6-甲基嘧啶-2,4-二胺;氯苯氨啶;氯苯氨啶,10 MM DMSO 溶液 |
| 英文名称 | Metoprine |
| 英文同义词 | 5-(3,4-dichlorophenyl)-6-MethylpyriMidine-2,4-diaMine;5-(3,4-Dichlorophenyl)-6-Methyl-2,4-pyriMidinediaMine;BW 197U;NSC 7364;SK 5265;Metoprine;methodichlorophen;2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE |
| CAS号 | 7761-45-7 |
| 分子式 | C11H10Cl2N4 |
| 分子量 | 269.13 |
| EINECS号 | |
| 相关类别 | Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals |
| Mol文件 | 7761-45-7.mol |
| 结构式 |  |
氯苯氨啶 性质
| 熔点 | 275-276℃ |
|---|---|
| 沸点 | 418.42°C (rough estimate) |
| 密度 | 1.447 |
| 折射率 | 1.6300 (estimate) |
| 储存条件 | Hygroscopic, Refrigerator, under inert atmosphere |
| 溶解度 | DMSO（略微加热）、甲醇（略微加热、超声处理） |
| 形态 | 固体 |
| 酸度系数(pKa) | 6.80±0.10(Predicted) |
| 颜色 | 灰白色至浅黄色 |
| 稳定性 | 吸湿性 |
Metoprine (BW 197U) 是一种有效的组胺 N-甲基转移酶 (HMT) 抑制剂。Metoprine 是一种二氨基嘧啶衍生物，可以透过血脑屏障，并通过抑制 HMT 增加脑组胺水平。Metoprine 是一种抗叶酸 (antifolate) 和抗肿瘤药。
Metoprine (BW 197U; 2-10 mg/kg; IP) ameliorates the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner.
Intraperitoneal administration of Metoprine produces various behavioral effects, including decreases in food intake and increases in water consumption.
| Animal Model: | Male Sprague-dawley rats (200-280g) |
| Dosage: | 2, 5, 10 mg/kg |
| Administration: | IP |
| Result: | Ameliorated the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner and significanty prolonged transfer latency at a high dose of 10 mg/kg. |