(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID

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(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Suppliers list
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(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID manufacturers

  • L-670,596
  • L-670,596 pictures
  • $2500.00
  • 2026-05-21
  • CAS:121083-05-4
  • Purity:
  • Supply Ability: 10g
(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Basic information
Product Name:(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID
Synonyms:L-670,596;(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID;2-(6,8-Difluoro-9-(4-(methylsulfonyl)benzyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid;L670,596,L 670,596;(-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(Methylsulfonyl)phenyl]Methyl]-1H-carbazole-1-aceticacid
CAS:121083-05-4
MF:C22H21F2NO4S
MW:433.47
EINECS:
Product Categories:Prostanoid receptor and related
Mol File:121083-05-4.mol
(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Structure
(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Chemical Properties
Boiling point 693.4±55.0 °C(Predicted)
density 1.43±0.1 g/cm3(Predicted)
storage temp. Store at RT
solubility Soluble to 100 mM in 1.1eq. NaOH
form Powder
pka4.56±0.10(Predicted)
Safety Information
MSDS Information
(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Usage And Synthesis
UsesL-670,596 is a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist.
DefinitionChEBI: 2-[6,8-difluoro-9-[(4-methylsulfonylphenyl)methyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid is a member of carbazoles.
Biological ActivityPotent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist (IC 50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA 2 = 9.0) and human platelet aggregation in vitro (IC 50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo .
in vivo

L-670596 (0.03mg/kg ; i.v.; single) inhibits arachidonic acid and U-44069 induced bronchoconstriction in the guinea pig[1].
L-670596 (2 mg/kg; i.v.; single) inhibits platelet aggregation to collagen in pigs[2].

Animal Model:Guinea pig (arachidonic acid and U-44069 induced bronchoconstriction model)[1].
Dosage:0.03mg/kg
Administration:Intravenous injection; single.
Result:Inhibited arachidonic acid and U-44069 induced bronchoconstriction.
(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Preparation Products And Raw materials
Tag:(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID(121083-05-4) Related Product Information
N-BENZYL-1,2,3,4-TETRAHYDROCARBAZOLE 7-Fluoroindole 5,7-Difluoroindole 4-METHYLSULFONYLBENZYLAMINE HYDROCHLORIDE 5-Fluoro-2-methylindole 6-(1H-INDOL-3-YL)HEXANOIC ACID 3-(1H-Pyrrol-2-yl)propanoic acid 5-Fluoro-2,3-dimethyl-1H-indole (-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID