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| | L-Prolinamide, N-[8-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxooctyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Basic information |
| | L-Prolinamide, N-[8-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxooctyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Chemical Properties |
| Boiling point | 896.6±65.0 °C(Predicted) | | density | 1.173±0.06 g/cm3(Predicted) | | pka | 12.94±0.46(Predicted) |
| | L-Prolinamide, N-[8-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxooctyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Usage And Synthesis |
| Uses | VH032-C6-NH-Boc is a Boc-modified VH032 (HY-120217) that serves as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins. VH032-C6-NH-Boc will remove the protecting group under acidic conditions and be directly used in PROTAC molecule synthesis. VH032-C6-NH-Boc is a key intermediate in the synthesis of PROTAC based on VHL ligand. |
| | L-Prolinamide, N-[8-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxooctyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Preparation Products And Raw materials |
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