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| | Pirmenol hydrochloride Basic information |
| Product Name: | Pirmenol hydrochloride | | Synonyms: | 4-[(2R,6S)-2,6-dimethyl-1-piperidyl]-1-phenyl-1-pyridin-2-yl-butan-1-o l hydrochloride;2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, monohydrochloride, cis-;2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, monohydrochloride, cis-(+-)-;2-Pyridinemethanol, a-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-a-phenyl-, monohydrochloride, rel- (9CI);CI 845;Cl 845;Pirmavar;pirmenol hydrochloride | | CAS: | 61477-94-9 | | MF: | C22H31ClN2O | | MW: | 374.95 | | EINECS: | | | Product Categories: | | | Mol File: | 61477-94-9.mol |  |
| | Pirmenol hydrochloride Chemical Properties |
| Melting point | 171-172 °C | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO : ≥ 28 mg/mL (74.68 mM) | | form | Solid | | color | White to yellow |
| | Pirmenol hydrochloride Usage And Synthesis |
| Description | Pirrnenol hydrochloride is a long-lasting Class la antiarrhythmic agent introduced
in Japan in 1994. The spectrum of antiarrhythmic activity of pirmenol includes atrial
and ventricular arrhythmias of diverse etiology. In clinical trials, pirmenol was found
effective in the short- and mid-term treatment of chronic premature ventricular
beats, with or without underlying heart disease. In patients with supraventricular
tachycardia, a single oral dose of pirmenol was highly effective in suppressing
induction of tachycardia with adequate hemodynamic tolerance. Since pirmenol is
highly effective by both intravenous and oral routes, it enables immediate
suppression, prevention, or termination of cardiac arrhythmias and facilitates the
transition to oral prophylactic therapy. | | Originator | Warner-Lamber (U.S.A.) | | Uses | Cardiac depressant (anti-arrhythmic). | | Brand name | Pirmavar (Parke-Davis);Plmenol. | | Toxics Screening Level | The initial threshold screening level (ITSL) for pirmenol is 3 μg/m3 baaed on an annual averaging time. |
| | Pirmenol hydrochloride Preparation Products And Raw materials |
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