2-Piperazineacetonitrile, 4-[7-(3-methoxy-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[2,3-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)-

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2-Piperazineacetonitrile, 4-[7-(3-methoxy-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[2,3-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)- Basic information
Product Name:2-Piperazineacetonitrile, 4-[7-(3-methoxy-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[2,3-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)-
Synonyms:2-Piperazineacetonitrile, 4-[7-(3-methoxy-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[2,3-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)-;KRAS G12C inhibitor 43
CAS:2648808-69-7
MF:C33H35N7O3
MW:577.68
EINECS:
Product Categories:
Mol File:2648808-69-7.mol
2-Piperazineacetonitrile, 4-[7-(3-methoxy-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[2,3-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)- Structure
2-Piperazineacetonitrile, 4-[7-(3-methoxy-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[2,3-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)- Chemical Properties
Boiling point 820.2±75.0 °C(Predicted)
density 1.246±0.06 g/cm3(Predicted)
pka9.17±0.40(Predicted)
Safety Information
MSDS Information
2-Piperazineacetonitrile, 4-[7-(3-methoxy-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[2,3-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)- Usage And Synthesis
UsesKRAS G12C inhibitor 43 (compound 59) is a potent KRAS G12C inhibitor. KRAS G12C inhibitor 43 shows antimigration and anti-proliferative activity with IC50s of 0.001-1 μM, >1 μM, >1 μM for H358, A549, HCC cells ,respectively[1].
IC 50KRas G12C
References[1] Xu Wei, et al. Pyridopyrimidine kras g12c mutant protein inhibitor. WO2021139678A1.
2-Piperazineacetonitrile, 4-[7-(3-methoxy-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[2,3-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)- Preparation Products And Raw materials
Tag:2-Piperazineacetonitrile, 4-[7-(3-methoxy-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[2,3-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)-(2648808-69-7) Related Product Information
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