| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
- p-Anisohydrazide
-
- $1.00
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2024-07-11
- CAS:3290-99-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20T
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| | p-Anisohydrazide Basic information |
| | p-Anisohydrazide Chemical Properties |
| Melting point | 136-140 °C(lit.) | | Boiling point | 294.38°C (rough estimate) | | density | 1.2265 (rough estimate) | | refractive index | 1.6180 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | form | powder to crystal | | pka | 12.65±0.10(Predicted) | | color | White to Orange to Green | | Water Solubility | Slightly soluble in water. | | BRN | 389017 | | InChI | 1S/C8H10N2O2/c1-12-7-4-2-6(3-5-7)8(11)10-9/h2-5H,9H2,1H3,(H,10,11) | | InChIKey | REKQLYUAUXYJSZ-UHFFFAOYSA-N | | SMILES | COc1ccc(cc1)C(=O)NN | | CAS DataBase Reference | 3290-99-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | RTECS | BZ4800000 | | HazardClass | IRRITANT | | HS Code | 2928009090 | | Storage Class | 11 - Combustible Solids | | Toxicity | LD50 ivn-mus: 178 mg/kg CSLNX* NX#00894 |
| | p-Anisohydrazide Usage And Synthesis |
| Uses | 4-Methoxybenzhydrazide is used as pharmaceutical intermediates and it is also involved in a variety of organic synthesis. | | Uses | 4-Methoxybenzhydrazide may be used to synthesize:
- N′-[(E)-5-bromo-2-hydroxy-3-methoxybenzylidene]-4-methoxybenzohydrazide monohydrate
- 2,5-bis(4-methoxyphenyl)-1,3,4-oxadiazole
- hydrazone ligands, which readily forms ruthenium(II) hydrazone complexes via reaction with [RuHCl(CO)(PPh3)3]
| | Synthesis Reference(s) | Journal of Medicinal Chemistry, 27, p. 1565, 1984 DOI: 10.1021/jm00378a007 | | Safety Profile | Poison by intravenous
route. Questionable carcinogen with
experimental neoplastigenic data. When heated to decomposition it emits toxic
fumes of Nox. | | Synthesis | 4-Methoxybenzoic acid hydrazide was synthesized according to literature [22]. A mixture of methyl 4-methoxybenzoate (1.66 g, 10 mmol) with 80% hydrazine hydrate (3.6 mL, 60 mmol) in anhydrous ethanol (20 mL) was heated and refluxed for 6 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give a white precipitate. The crude product was recrystallized from anhydrous ethanol to give 4-methoxybenzohydrazide as colorless needle-like crystals. Yield 96%, melting point 138-139°C (literature values in accordance). | | References | [1] Journal of the American Chemical Society, 2013, vol. 135, # 15, p. 5656 - 5668
[2] Journal of the Chilean Chemical Society, 2012, vol. 57, # 4, p. 1492 - 1496
[3] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2017, vol. 174, p. 272 - 278
[4] European Journal of Medicinal Chemistry, 1985, vol. 20, # 3, p. 257 - 266
[5] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 16, p. 4842 - 4850 |
| | p-Anisohydrazide Preparation Products And Raw materials |
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