| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Email: |
info@lynnchem.com |
| Products Intro: |
Product Name:ophiobolin C
CAS:19022-51-6
Purity:>98% by HPLC Package:1mg;5mg
|
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Email: |
info@novachemistry.com |
| Products Intro: |
Product Name:Ophiobolin C
CAS:19022-51-6
Purity:>98% by HPLC Package:1mg;5mg
|
- Ophiobolin C
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- $3120.00
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2026-07-27
- CAS:19022-51-6
- Purity:
- Supply Ability: 10g
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| | ophiobolin C Basic information |
| Product Name: | ophiobolin C | | Synonyms: | ophiobolin C;3-Hydroxy-5-oxoophiobola-7,19-dien-25-al;Zizanin A;Dicyclopenta[a,d]cyclooctene-4-carboxaldehyde, 7-[(1S)-1,5-dimethyl-4-hexen-1-yl]-1,2,3,3a,6,6a,7,8,9,9a,10,10a-dodecahydro-1-hydroxy-1,9a-dimethyl-3-oxo-, (1R,3aS,6aS,7R,9aR,10aS)- | | CAS: | 19022-51-6 | | MF: | C25H38O3 | | MW: | 386.57 | | EINECS: | | | Product Categories: | | | Mol File: | 19022-51-6.mol |  |
| | ophiobolin C Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | A solid |
| | ophiobolin C Usage And Synthesis |
| Description | Ophiobolin C is a sesterterpenoid fungal phytoxin produced by many species of the genus Bipolaris. It has been identified as an antagonist of chemokine receptor CCR5 binding (IC50 = 40 μM) to the envelope protein gp120 and to CD4, which is known to mediate HIV-1 viral entry into cells. Ophiobolin C is also reported to be cytotoxic to chronic lymphocytic leukemia cells (LC50 = 8 nM). | | Uses | Ophiobolin C is a member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus Bipolaris. Ophiobolin C inhibits human CCR5 binding to the envelope protein gp120 and CD4 that mediates HIV-1 entry into cells. Blockade of this binding was considered by scientists at Merck as a potential new mode of action for the treatment of HIV-1 infection. | | Uses | Ophiobolin C is an inhibitor of human CCR5 binding to HIV-1 gp120. | | Definition | ChEBI: Ophiobolin C is a sesterterpenoid that is ophiobolane with a hydroxy group at position 3, oxo group at positions 5, formyl group at position 7, and double bonds at positions 7-8 and 19-20. It has a role as an antineoplastic agent, an apoptosis inducer, an Aspergillus metabolite, a chemokine receptor 5 antagonist, a nematicide and a fungal metabolite. It is a cyclic ketone, an enal, a sesterterpenoid, a tertiary alcohol, a carbotricyclic compound and an olefinic compound. It derives from a hydride of an ophiobolane. | | IC 50 | CCR5; HIV-1 | | References | [1] HIRANTHI JAYASURIYA. Isolation and Structure of Antagonists of Chemokine Receptor (CCR5)[J]. Journal of Natural Products , 2004, 67 6: 1036-1038. DOI: 10.1021/np049974l
[2] TANJA THORSKOV BLADT. Bio-activity and dereplication-based discovery of ophiobolins and other fungal secondary metabolites targeting leukemia cells.[J]. Molecules, 2013, 18 12: 14629-14650. DOI: 10.3390/molecules181214629 |
| | ophiobolin C Preparation Products And Raw materials |
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