1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide

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1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide Suppliers list
Company Name: Zhende Chemical Technology (Shanghai) Co., Ltd.  
Tel: 15601952568
Email: sales4@myuchem.com
Products Intro: Product Name:1-Cyclohexyl-3-(cyclopropylmethyl)-N-((3-methylisoxazol-5-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide , hNPR1 inhibitor JS-11
CAS:1394592-04-1
Purity:0.97 Package:1g;5g;10g
Company Name: Bide Pharmatech Ltd.  
Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Products Intro: Product Name:1-Cyclohexyl-3-(cyclopropylmethyl)-N-((3-methylisoxazol-5-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide
CAS:1394592-04-1
Purity:95% Package:10mg;25mg;50mg;100mg;250mg Remarks:BD01418154
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:JS11
CAS:1394592-04-1
Package:10mg;50mg
Company Name: Guangzhou New Century Technology Co., Ltd.  
Tel: 020-13113998854 13113998854
Email: 1094589719@qq.com
Products Intro: CAS:1394592-04-1
1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide Basic information
Product Name:1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide
Synonyms:1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide;1-cyclohexyl-3-(cyclopropylmethyl)-N-((3-methylisoxazol-5-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide;1-Cyclohexyl-3-(cyclopropylmethyl)-N-((3-methylisoxazol-5-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide , hNPR1 inhibitor JS-11;JS11
CAS:1394592-04-1
MF:C23H28N4O3
MW:408.49
EINECS:
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Mol File:1394592-04-1.mol
1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide Structure
1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide Chemical Properties
Boiling point 617.4±55.0 °C(Predicted)
density 1.286±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka12.95±0.20(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide Usage And Synthesis
UsesJS11 is an inhibitor for natriuretic polypeptide receptor 1 (Npr1) with an IC50 of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models[1].
References[1] Hoon MA, et al., Compositions and methods for the inhibition of pruritus. WO2019090039.
1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide Preparation Products And Raw materials
Tag:1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide(1394592-04-1) Related Product Information
1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide ATRIAL NATRIURETIC FACTOR (4-28) (HUMAN) NPRA agonist-11 6-HYDROXY-INDOLE-2,3-DIONE URODILATIN HUMAN BNP-32 (HUMAN)