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| | ARN11391 Basic information |
| Product Name: | ARN11391 | | Synonyms: | ARN11391;2H-Indazole-3-carboxamide, 2-ethyl-4,5,6,7-tetrahydro-N-[2-[(tetrahydro-2H-pyran-2-yl)methoxy]phenyl]- | | CAS: | 1214569-31-9 | | MF: | C22H29N3O3 | | MW: | 383.48 | | EINECS: | | | Product Categories: | | | Mol File: | 1214569-31-9.mol |  |
| | ARN11391 Chemical Properties |
| Boiling point | 525.672±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.269±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | -10 to -25°C | | solubility | DMSO: 2mg/mL, clear | | form | powder | | pka | 12.955±0.70(predicted) | | color | white to beige |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | ARN11391 Usage And Synthesis |
| Uses | ARN 11391 is a selective enhancer of inositol triphosphate receptor type 1 (ITPR1). ARN 11391 can be used in the study of spinocerebellar ataxia[1]. | | Biological Activity | Selective inositol triphosphate receptor type 1 (ITPR1) potentiator for wild-type as well as two ITPR1 SCA29 mutants, R269W or T267M.
ARN11391 is a selective inositol triphosphate receptor type 1 (ITPR1), but not ITPR2 or ITPR3, potentiator (open channel probability (Po) = 0.2 with 20 μM ARN11391 and <0.01 without by on-nucleus nuclear patch-clamp using TPR1-YFP-expressing HEK293 cells) th at potenitates IP3- (by photolysis of caged IP3) and UPT-induced calcium increase in HEK293 transfectants expressing wild-type as well as ITPR1 SCA29 mutants, R269W or T267M (5 μM UTP with or without 10 μM ARN11391). | | References | [1] Genovese M, et al. Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening. PNAS Nexus. 2022 Dec 9;2(1):pgac288. DOI:10.1093/pnasnexus/pgac288 |
| | ARN11391 Preparation Products And Raw materials |
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