(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride

(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride Suppliers list

Company Name:	Shanghai Boyle Chemical Co., Ltd.
Tel:
Email:	sales@boylechem.com

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	18930552037
Email:	3bsc@sina.com

Company Name:	Chembest Research Laboratories Limited
Tel:	021-20908456
Email:	sales@BioChemBest.com

(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride manufacturers

(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride Basic information

Product Name:	(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride
Synonyms:	(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride;(6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenolhydrochloride;(S)-6-(propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride;(6S)-;8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]aMino]-;CEXBONHIOKGWNU-NUDVEOEASA-N;(S)-6-(propyl(2-(thiophen-2-yl)ethyl)aMino)-5,6,7,8-tetrahydronaphthalen-1-ol;1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]aMino]-, hydrochloride, (6S)-
CAS:	125572-93-2
MF:	C19H26ClNOS
MW:	351.93
EINECS:	603-080-0
Product Categories:	APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;API
Mol File:	125572-93-2.mol

(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride Chemical Properties

Melting point	114-117°C
density	1.2g/cm3 at 20℃
vapor pressure	0-0Pa at 20-25℃
storage temp.	room temp
solubility	Acetone (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly)
form	solid
color	white to off-white
Stability:	Hygroscopic
InChI	1S/C19H25NOS.ClH/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21;/h3-7,13,16,21H,2,8-12,14H2,1H3;1H/t16-;/m0./s1
InChIKey	CEXBONHIOKGWNU-NTISSMGPSA-N
SMILES	Cl.CCCN(CCc1cccs1)[C@H]2CCc3c(O)cccc3C2
LogP	3.1 at 20℃ and pH7
Surface tension	72.3mN/m at 1g/L and 20℃

Safety Information

MSDS Information

(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride Usage And Synthesis

Chemical Properties	White to Off-White Solid
Uses	It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson’s disease.
Biochem/physiol Actions	Rotigotine is a dopamine receptor agonist with preference for D3 receptors over D2 and D1. As such, it is an effective anti-Parkinsonian agent. Racemic rotigotine is about 50 times as potent as quinpirole, the gold standard D2 agonist.
in vivo	In primed rats, Rotigotine (N-0923) (0.035, 0.1 and 0.35 mg/kg) induces contralateral turning behavior in a dose dependent manner. In drug naive rats, the turning behavior induced by Rotigotine, either alone or in combination with SCH 39166, is reduced compared to primed rats^[3].
IC 50	D₃ Receptor: 0.71 nM (Ki); D₂ Receptor: 4-15 nM (Ki); D₅ Receptor: 4-15 nM (Ki); D₄ Receptor: 4-15 nM (Ki); D₁ Receptor: 83 nM (Ki); α1A: 176 nM (Ki); α1B: 273 nM (Ki); α2A: 338 nM (Ki); α2B: 27 nM (Ki); 5-HT_1A Receptor: 30 nM (Ki); 5-HT₇ Receptor: 86 nM (Ki)
storage	room temperature (desiccate)

(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride Preparation Products And Raw materials

Tag:(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride(125572-93-2) Related Product Information

2-Naphthalenamine, 1,2,3,4-tetrahydro-N-methyl-N-propyl-, hydrochloride Methyl-(2-thiophen-2-yl-ethyl)-amine hydrochloride 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- (6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride Thiophene-2-ethylamine ROTIGOTINE