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| | 6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE Basic information |
| Product Name: | 6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE | | Synonyms: | 6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE;Quinoline, 6-chloro-1,2,3,4-tetrahydro- | | CAS: | 49716-18-9 | | MF: | C9H10ClN | | MW: | 167.64 | | EINECS: | | | Product Categories: | | | Mol File: | 49716-18-9.mol |  |
| | 6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE Chemical Properties |
| Melting point | 41 °C | | Boiling point | 125-127 °C(Press: 3 Torr) | | density | 1.162±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 4.43±0.20(Predicted) | | Appearance | Light brown to brown Solid |
| HazardClass | IRRITANT | | HS Code | 2933499090 |
| | 6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE Usage And Synthesis |
| Uses | 6-Chloro-1,2,3,4-tetrahydroquinoline (cas# 49716-18-9) is a compound useful in organic synthesis. | | Synthesis Reference(s) | Tetrahedron Letters, 28, p. 77, 1987 DOI: 10.1016/S0040-4039(00)95653-3 | | Synthesis | GENERAL STEPS: PdNPore (2.7 mg, 5 mol%) was dissolved in acetonitrile (5 mL) and 6-chloroquinoline (81.8 mg, 0.5 mmol) was added. The reaction mixture was placed in a magnetic stirrer at 30 °C for 16 h under hydrogen atmosphere (5 bar). After completion of the reaction, it was purified by column chromatography (silica gel, 200-300 mesh, ethyl acetate as eluent) to afford 6-chloro-1,2,3,4-tetrahydroquinoline (69.57 mg, 83% yield). | | References | [1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 17, p. 7956 - 7967
[2] Angewandte Chemie - International Edition, 2016, vol. 55, # 50, p. 15656 - 15661
[3] Angew. Chem., 2016, vol. 128, # 50, p. 15885 - 15890,6
[4] Organic Letters, 2013, vol. 15, # 7, p. 1484 - 1487
[5] Chemical Communications, 2013, vol. 49, # 63, p. 7052 - 7054 |
| | 6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE Preparation Products And Raw materials |
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